Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules

Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules

Summary: The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids results in pro-inflammatory responses. Here, we screened available vertebrate genome data and found that GPR84 is...

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Bibliographic Details
Main Authors: Amadeus Samuel Schulze, Gunnar Kleinau, Rosanna Krakowsky, David Rochmann, Ranajit Das, Catherine L. Worth, Petra Krumbholz, Patrick Scheerer, Claudia Stäubert
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
Evolutionary biology
Evolutionary processes
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013591

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