HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults
Abstract Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults. Methods A total of 2,909 genotyped patients were enrolled in thi...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-024-02039-7 |
| _version_ | 1797273401349373952 |
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| author | Siobhán O.’ Sullivan Cynthia Al Hageh Andreas Henschel Stephanie Chacar Antoine Abchee Pierre Zalloua Moni Nader |
| author_facet | Siobhán O.’ Sullivan Cynthia Al Hageh Andreas Henschel Stephanie Chacar Antoine Abchee Pierre Zalloua Moni Nader |
| author_sort | Siobhán O.’ Sullivan |
| collection | DOAJ |
| description | Abstract Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults. Methods A total of 2,909 genotyped patients were enrolled in this study. Genome Wide Association Study was conducted, comparing T2D patients to non-diabetic older adults aged ≥ 60, ≥ 65, or ≥ 70 years, respectively. Binomial logistic regressions were applied to examine the association between T2D and various risk factors. Stepwise logistic regression was conducted to explore the impact of low HDL (HDL < 40 mg/dl) on the relationship between the genetic variants and T2D. A further validation step using data from the UK Biobank with 53,779 subjects was performed. Results The association of T2D with both low HDL and family history of T2D increased with the age of control groups. T2D susceptibility variants (rs7756992, rs4712523 and rs10946403) were associated with T2D, more significantly with increased age of the control group. These variants had stronger effects on T2D risk when combined with low HDL cholesterol levels, especially in older control groups. Conclusions The findings highlight a critical role of age, genetic predisposition, and HDL levels in T2D risk. The findings suggest that individuals over 70 years who have high HDL levels without the T2D susceptibility alleles may be at the lowest risk of developing T2D. These insights can inform tailored preventive strategies for older adults, enhancing personalized T2D risk assessments and interventions. |
| first_indexed | 2024-03-07T14:43:50Z |
| format | Article |
| id | doaj.art-9329964cad374e0ca2addae18ae230ce |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-07T14:43:50Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-9329964cad374e0ca2addae18ae230ce2024-03-05T20:08:03ZengBMCLipids in Health and Disease1476-511X2024-02-0123111110.1186/s12944-024-02039-7HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adultsSiobhán O.’ Sullivan0Cynthia Al Hageh1Andreas Henschel2Stephanie Chacar3Antoine Abchee4Pierre Zalloua5Moni Nader6Department of Biological Sciences, College of Medicine and Health Sciences, Khalifa UniversityDepartment of Public Health and Epidemiology, College of Medicine and Health Sciences, Khalifa UniversityDepartment of Computer Science, College of Engineering, Khalifa UniversityDepartment of Medical Sciences, College of Medicine and Health Sciences, Khalifa UniversityFaculty of Medicine, University of BalamandFaculty of Medicine, University of BalamandDepartment of Medical Sciences, College of Medicine and Health Sciences, Khalifa UniversityAbstract Background Type 2 Diabetes (T2D) is influenced by genetic, environmental, and ageing factors. Ageing pathways exacerbate metabolic diseases. This study aimed to examine both clinical and genetic factors of T2D in older adults. Methods A total of 2,909 genotyped patients were enrolled in this study. Genome Wide Association Study was conducted, comparing T2D patients to non-diabetic older adults aged ≥ 60, ≥ 65, or ≥ 70 years, respectively. Binomial logistic regressions were applied to examine the association between T2D and various risk factors. Stepwise logistic regression was conducted to explore the impact of low HDL (HDL < 40 mg/dl) on the relationship between the genetic variants and T2D. A further validation step using data from the UK Biobank with 53,779 subjects was performed. Results The association of T2D with both low HDL and family history of T2D increased with the age of control groups. T2D susceptibility variants (rs7756992, rs4712523 and rs10946403) were associated with T2D, more significantly with increased age of the control group. These variants had stronger effects on T2D risk when combined with low HDL cholesterol levels, especially in older control groups. Conclusions The findings highlight a critical role of age, genetic predisposition, and HDL levels in T2D risk. The findings suggest that individuals over 70 years who have high HDL levels without the T2D susceptibility alleles may be at the lowest risk of developing T2D. These insights can inform tailored preventive strategies for older adults, enhancing personalized T2D risk assessments and interventions.https://doi.org/10.1186/s12944-024-02039-7Older age groupsGenetic variantsHDLDiabetes risk |
| spellingShingle | Siobhán O.’ Sullivan Cynthia Al Hageh Andreas Henschel Stephanie Chacar Antoine Abchee Pierre Zalloua Moni Nader HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults Lipids in Health and Disease Older age groups Genetic variants HDL Diabetes risk |
| title | HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| title_full | HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| title_fullStr | HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| title_full_unstemmed | HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| title_short | HDL levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| title_sort | hdl levels modulate the impact of type 2 diabetes susceptibility alleles in older adults |
| topic | Older age groups Genetic variants HDL Diabetes risk |
| url | https://doi.org/10.1186/s12944-024-02039-7 |
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