Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan
We compared the clinical characteristics and outcome of vaccinated hospitalized COVID-19 patients with unvaccinated hospitalized COVID-19 patients. A retrospective cohort study was conducted at the Sindh Infectious Diseases Hospital and Research Center, Karachi, Pakistan. A total of 1407 hospitalize...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/7/1178 |
| _version_ | 1797587314136842240 |
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| author | Muneeba Ahsan Sayeed Elisha Shalim Fizza Farooqui Shaiza Farman Maheen Khan Anika Iqbal Ishfaque Ahmed Abdul Wahid Rajput Abdul Razzaque Saeed Quraishy |
| author_facet | Muneeba Ahsan Sayeed Elisha Shalim Fizza Farooqui Shaiza Farman Maheen Khan Anika Iqbal Ishfaque Ahmed Abdul Wahid Rajput Abdul Razzaque Saeed Quraishy |
| author_sort | Muneeba Ahsan Sayeed |
| collection | DOAJ |
| description | We compared the clinical characteristics and outcome of vaccinated hospitalized COVID-19 patients with unvaccinated hospitalized COVID-19 patients. A retrospective cohort study was conducted at the Sindh Infectious Diseases Hospital and Research Center, Karachi, Pakistan. A total of 1407 hospitalized COVID-19 positive patients were included from April 2021 to March 2022, of which 812 (57.71%) were males. Of the 1407, 378 (26.87%) patients were vaccinated while 1029 (73.13%) were unvaccinated. Of the vaccinated patients, 160 (42.32%) were partially vaccinated while 218 (57.68%) were fully vaccinated (vaccine breakthrough infection). Fewer unvaccinated COVID-19 patients survived compared to vaccinated patients (62.5% vs. 70%, RR 0.89, 95% CI: 0.82–0.96, <i>p</i>-value = 0.004). Despite there being more vaccinated patients above 60 years of age (60.05% vs. 47.13%), their risk of mortality was lower by 43% (OR = 0.578; CI = 0.4201 to 0.7980, <i>p</i> = 0.0009). On survival analysis, vaccinated patients had better 30-day survival compared to unvaccinated patients (<i>p</i> = 0.028). Moreover, comparing waves 3–5, unvaccinated patients of wave 4, which was driven by the delta variant, had the worst survival (51.8%, <i>p</i> ≤ 0.001) while vaccinated patients of wave 3 (driven by the alpha variant) had the best survival (71.6%). |
| first_indexed | 2024-03-11T00:35:23Z |
| format | Article |
| id | doaj.art-932a46f4affe423c93e13a9e96162ab2 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T00:35:23Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-932a46f4affe423c93e13a9e96162ab22023-11-18T21:40:43ZengMDPI AGVaccines2076-393X2023-06-01117117810.3390/vaccines11071178Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, PakistanMuneeba Ahsan Sayeed0Elisha Shalim1Fizza Farooqui2Shaiza Farman3Maheen Khan4Anika Iqbal5Ishfaque Ahmed6Abdul Wahid Rajput7Abdul Razzaque8Saeed Quraishy9Sindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanSindh Infectious Diseases Hospital & Research Center, Karachi 75300, PakistanWe compared the clinical characteristics and outcome of vaccinated hospitalized COVID-19 patients with unvaccinated hospitalized COVID-19 patients. A retrospective cohort study was conducted at the Sindh Infectious Diseases Hospital and Research Center, Karachi, Pakistan. A total of 1407 hospitalized COVID-19 positive patients were included from April 2021 to March 2022, of which 812 (57.71%) were males. Of the 1407, 378 (26.87%) patients were vaccinated while 1029 (73.13%) were unvaccinated. Of the vaccinated patients, 160 (42.32%) were partially vaccinated while 218 (57.68%) were fully vaccinated (vaccine breakthrough infection). Fewer unvaccinated COVID-19 patients survived compared to vaccinated patients (62.5% vs. 70%, RR 0.89, 95% CI: 0.82–0.96, <i>p</i>-value = 0.004). Despite there being more vaccinated patients above 60 years of age (60.05% vs. 47.13%), their risk of mortality was lower by 43% (OR = 0.578; CI = 0.4201 to 0.7980, <i>p</i> = 0.0009). On survival analysis, vaccinated patients had better 30-day survival compared to unvaccinated patients (<i>p</i> = 0.028). Moreover, comparing waves 3–5, unvaccinated patients of wave 4, which was driven by the delta variant, had the worst survival (51.8%, <i>p</i> ≤ 0.001) while vaccinated patients of wave 3 (driven by the alpha variant) had the best survival (71.6%).https://www.mdpi.com/2076-393X/11/7/1178COVID-19vaccinatedunvaccinatedcomparisonoutcomehospitalized |
| spellingShingle | Muneeba Ahsan Sayeed Elisha Shalim Fizza Farooqui Shaiza Farman Maheen Khan Anika Iqbal Ishfaque Ahmed Abdul Wahid Rajput Abdul Razzaque Saeed Quraishy Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan Vaccines COVID-19 vaccinated unvaccinated comparison outcome hospitalized |
| title | Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan |
| title_full | Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan |
| title_fullStr | Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan |
| title_full_unstemmed | Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan |
| title_short | Comparison of the Disease Severity and Outcome of Vaccinated COVID-19 Patients with Unvaccinated Patients in a Specialized COVID-19 Facility: A Retrospective Cohort Study from Karachi, Pakistan |
| title_sort | comparison of the disease severity and outcome of vaccinated covid 19 patients with unvaccinated patients in a specialized covid 19 facility a retrospective cohort study from karachi pakistan |
| topic | COVID-19 vaccinated unvaccinated comparison outcome hospitalized |
| url | https://www.mdpi.com/2076-393X/11/7/1178 |
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