Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves
Objective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-05-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/pdf_16_54cb0f98a7ee0e5768a3b2253dfac9cb.html |
| _version_ | 1818564216979718144 |
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| author | Badrul Alam Fahima Akter Nahida Parvin Rashna Sharmin Pia Sharmin Akter Jesmin Chowdhury Kazi Sifath-E-Jahan Ekramul Haque Haque |
| author_facet | Badrul Alam Fahima Akter Nahida Parvin Rashna Sharmin Pia Sharmin Akter Jesmin Chowdhury Kazi Sifath-E-Jahan Ekramul Haque Haque |
| author_sort | Badrul Alam |
| collection | DOAJ |
| description | Objective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO-) as well as inhibition of total ROS generation, and assessment of reducing power were used to evaluate antioxidant potential of MPBL. Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (p |
| first_indexed | 2024-12-14T01:26:15Z |
| format | Article |
| id | doaj.art-932c2a6a481f402991826d4eed7e2691 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-14T01:26:15Z |
| publishDate | 2013-05-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-932c2a6a481f402991826d4eed7e26912022-12-21T23:22:10ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492013-05-013211212516Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leavesBadrul Alam0Fahima Akter1Nahida Parvin2Rashna Sharmin Pia3Sharmin Akter4Jesmin Chowdhury5Kazi Sifath-E-Jahan6Ekramul Haque Haque7Department of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, BangladeshDepartment of Pharmacy, University of Rajshahi, Rajshahi, BangladeshObjective:The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities ofthe methanolic extract of Piper betle leaves (MPBL). Materials and Methods: MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. Analgesic activity of MPBL was evaluated by hot plate, writhing, and formalin tests. Total phenolic and flavonoids content, total antioxidant activity, scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, peroxynitrate (ONOO-) as well as inhibition of total ROS generation, and assessment of reducing power were used to evaluate antioxidant potential of MPBL. Results: The extract of MPBL, at the dose of 100 and 200 mg/kg, produced a significant (phttp://ajp.mums.ac.ir/pdf_16_54cb0f98a7ee0e5768a3b2253dfac9cb.htmlAnalgesicantioxidantanti-inflammatoryPiper betle |
| spellingShingle | Badrul Alam Fahima Akter Nahida Parvin Rashna Sharmin Pia Sharmin Akter Jesmin Chowdhury Kazi Sifath-E-Jahan Ekramul Haque Haque Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves Avicenna Journal of Phytomedicine Analgesic antioxidant anti-inflammatory Piper betle |
| title | Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves |
| title_full | Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves |
| title_fullStr | Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves |
| title_full_unstemmed | Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves |
| title_short | Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves |
| title_sort | antioxidant analgesic and anti inflammatory activities of the methanolic extract of piper betle leaves |
| topic | Analgesic antioxidant anti-inflammatory Piper betle |
| url | http://ajp.mums.ac.ir/pdf_16_54cb0f98a7ee0e5768a3b2253dfac9cb.html |
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