Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016
Abstract Background Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are available about the prevalence of TTIs in patients before blood transfusion...
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| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3051-7 |
| _version_ | 1828394125107396608 |
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| author | Wei-Wei Cao Rong-Rong Zhou Xinghua Ou Ling-Xi Shi Chao-Qi Xiao Ting-Yin Chen Hua Tan Xue-Gong Fan Bi-Juan Li Ning Li |
| author_facet | Wei-Wei Cao Rong-Rong Zhou Xinghua Ou Ling-Xi Shi Chao-Qi Xiao Ting-Yin Chen Hua Tan Xue-Gong Fan Bi-Juan Li Ning Li |
| author_sort | Wei-Wei Cao |
| collection | DOAJ |
| description | Abstract Background Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are available about the prevalence of TTIs in patients before blood transfusion in China. This study aimed to investigate the seroprevalence of four TTIs among patients before blood transfusion in Xiangya Hospital Central South University, China. Methods From 2011 to 2016, 442,121 hospitalized patients before possible blood transfusion were tested for hepatitis B surface antigen (HBsAg), anti-HCV, syphilis antibody (anti-TP) and anti-HIV. Results Of the 442,121 patients, the overall positivity of the four TTI serum markers was 15.35%. The positive rates of HBsAg, anti-HCV, anti-HIV and anti-TP were 10.98, 1.43, 0.16 and 2.78%, respectively. TTI serum markers showed a significant difference by gender, with positive rates of 17.98% for males and 12.79% for females. The prevalence of TTI serum markers varied significantly by age. The overall co-infection rate was 0.63%, and the top three multiple infections were HBV-TP, HBV-HCV, and HCV-TP. The co-infection rates of HBV-TP and HBV-HCV showed a significant decrease from 2011 to 2016, while the rates of other co-infections remained stable. Conclusions The prevalence of TTIs in patients before blood transfusion is much higher compared to that in blood donors in the region. The infection rates of HIV and TP increased, and the infection rate of HBsAg decreased in recent years. |
| first_indexed | 2024-12-10T07:50:22Z |
| format | Article |
| id | doaj.art-932c3284f08046abb54a253dbd6906c7 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-10T07:50:22Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-932c3284f08046abb54a253dbd6906c72022-12-22T01:57:03ZengBMCBMC Infectious Diseases1471-23342018-04-011811710.1186/s12879-018-3051-7Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016Wei-Wei Cao0Rong-Rong Zhou1Xinghua Ou2Ling-Xi Shi3Chao-Qi Xiao4Ting-Yin Chen5Hua Tan6Xue-Gong Fan7Bi-Juan Li8Ning Li9Department of Blood Transfusion of Xiangya Hospital, Central South UniversityDepartment of Infectious Diseases, Xiangya Hospital, Central South UniversityCenter for Disease Prevention and Control of ChangshaDepartment of Blood Transfusion of Xiangya Hospital, Central South UniversityDepartment of Blood Transfusion of Xiangya Hospital, Central South UniversityDepartment of Information of Xiangya Hospital, Central South UniversityCenter for Disease Prevention and Control of Kaifu DistrictDepartment of Infectious Diseases, Xiangya Hospital, Central South UniversityDepartment of Blood Transfusion of Xiangya Hospital, Central South UniversityDepartment of Blood Transfusion of Xiangya Hospital, Central South UniversityAbstract Background Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are available about the prevalence of TTIs in patients before blood transfusion in China. This study aimed to investigate the seroprevalence of four TTIs among patients before blood transfusion in Xiangya Hospital Central South University, China. Methods From 2011 to 2016, 442,121 hospitalized patients before possible blood transfusion were tested for hepatitis B surface antigen (HBsAg), anti-HCV, syphilis antibody (anti-TP) and anti-HIV. Results Of the 442,121 patients, the overall positivity of the four TTI serum markers was 15.35%. The positive rates of HBsAg, anti-HCV, anti-HIV and anti-TP were 10.98, 1.43, 0.16 and 2.78%, respectively. TTI serum markers showed a significant difference by gender, with positive rates of 17.98% for males and 12.79% for females. The prevalence of TTI serum markers varied significantly by age. The overall co-infection rate was 0.63%, and the top three multiple infections were HBV-TP, HBV-HCV, and HCV-TP. The co-infection rates of HBV-TP and HBV-HCV showed a significant decrease from 2011 to 2016, while the rates of other co-infections remained stable. Conclusions The prevalence of TTIs in patients before blood transfusion is much higher compared to that in blood donors in the region. The infection rates of HIV and TP increased, and the infection rate of HBsAg decreased in recent years.http://link.springer.com/article/10.1186/s12879-018-3051-7Transfusion-transmissible infectionsHuman immunodeficiency virusViral hepatitisTreponema pallidumBlood transfusion |
| spellingShingle | Wei-Wei Cao Rong-Rong Zhou Xinghua Ou Ling-Xi Shi Chao-Qi Xiao Ting-Yin Chen Hua Tan Xue-Gong Fan Bi-Juan Li Ning Li Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 BMC Infectious Diseases Transfusion-transmissible infections Human immunodeficiency virus Viral hepatitis Treponema pallidum Blood transfusion |
| title | Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 |
| title_full | Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 |
| title_fullStr | Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 |
| title_full_unstemmed | Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 |
| title_short | Prevalence of hepatitis B virus, hepatitis C virus, human immunodeficiency virus and Treponema pallidum infections in hospitalized patients before transfusion in Xiangya hospital Central South University, China from 2011 to 2016 |
| title_sort | prevalence of hepatitis b virus hepatitis c virus human immunodeficiency virus and treponema pallidum infections in hospitalized patients before transfusion in xiangya hospital central south university china from 2011 to 2016 |
| topic | Transfusion-transmissible infections Human immunodeficiency virus Viral hepatitis Treponema pallidum Blood transfusion |
| url | http://link.springer.com/article/10.1186/s12879-018-3051-7 |
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