Bone Pathology in Multiple Myeloma: Diagnosis and Treatment
Multiple myeloma is the most common primary bone disease. Incidence has been reported as 3/100.000 in the United States. This neoplasia is characterized by osteolytic bone destruction and monoclonal proliferation of plasma cells. Multiple myeloma is the most common haematologic malignancy after Non-...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kare Publishing
2020-06-01
|
| Series: | Boğaziçi Tıp Dergisi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-65365 |
| _version_ | 1797913268603322368 |
|---|---|
| author | Erhan Okay Korhan Özkan |
| author_facet | Erhan Okay Korhan Özkan |
| author_sort | Erhan Okay |
| collection | DOAJ |
| description | Multiple myeloma is the most common primary bone disease. Incidence has been reported as 3/100.000 in the United States. This neoplasia is characterized by osteolytic bone destruction and monoclonal proliferation of plasma cells. Multiple myeloma is the most common haematologic malignancy after Non-Hodgkin lymphoma and the most common primary bone malignancy in elderly population. Orthopaedic complaints include pain, pathologic fracture, osteoporosis, hypercalcemia and spinal cord compression. Chemotherapy constitutes the main treatment. Surgical intervention should be as minimal as possible and chemotherapy should be started as soon as possible. The risk of infection should also be considered. This review aimed to synthesize the diagnosis and treatment of bone involvement in myeloma disease. |
| first_indexed | 2024-04-10T12:10:18Z |
| format | Article |
| id | doaj.art-932cfbf34c934c8eb0755a9b73d9506a |
| institution | Directory Open Access Journal |
| issn | 2149-0287 |
| language | English |
| last_indexed | 2024-04-10T12:10:18Z |
| publishDate | 2020-06-01 |
| publisher | Kare Publishing |
| record_format | Article |
| series | Boğaziçi Tıp Dergisi |
| spelling | doaj.art-932cfbf34c934c8eb0755a9b73d9506a2023-02-15T16:16:03ZengKare PublishingBoğaziçi Tıp Dergisi2149-02872020-06-0172707410.14744/bmj.2020.65365BMJ-65365Bone Pathology in Multiple Myeloma: Diagnosis and TreatmentErhan Okay0Korhan Özkan1Istanbul Medeniyet University Goztepe Education and Research Hospital, Department of Orthopaedics, IstanbulIstanbul Medeniyet University Goztepe Education and Research Hospital, Department of Orthopaedics, IstanbulMultiple myeloma is the most common primary bone disease. Incidence has been reported as 3/100.000 in the United States. This neoplasia is characterized by osteolytic bone destruction and monoclonal proliferation of plasma cells. Multiple myeloma is the most common haematologic malignancy after Non-Hodgkin lymphoma and the most common primary bone malignancy in elderly population. Orthopaedic complaints include pain, pathologic fracture, osteoporosis, hypercalcemia and spinal cord compression. Chemotherapy constitutes the main treatment. Surgical intervention should be as minimal as possible and chemotherapy should be started as soon as possible. The risk of infection should also be considered. This review aimed to synthesize the diagnosis and treatment of bone involvement in myeloma disease.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-65365chemotherapyintramedullary nailing; myeloma; osteolytic bone destruction; pathologic fracture. |
| spellingShingle | Erhan Okay Korhan Özkan Bone Pathology in Multiple Myeloma: Diagnosis and Treatment Boğaziçi Tıp Dergisi chemotherapy intramedullary nailing; myeloma; osteolytic bone destruction; pathologic fracture. |
| title | Bone Pathology in Multiple Myeloma: Diagnosis and Treatment |
| title_full | Bone Pathology in Multiple Myeloma: Diagnosis and Treatment |
| title_fullStr | Bone Pathology in Multiple Myeloma: Diagnosis and Treatment |
| title_full_unstemmed | Bone Pathology in Multiple Myeloma: Diagnosis and Treatment |
| title_short | Bone Pathology in Multiple Myeloma: Diagnosis and Treatment |
| title_sort | bone pathology in multiple myeloma diagnosis and treatment |
| topic | chemotherapy intramedullary nailing; myeloma; osteolytic bone destruction; pathologic fracture. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=bmj&un=BMJ-65365 |
| work_keys_str_mv | AT erhanokay bonepathologyinmultiplemyelomadiagnosisandtreatment AT korhanozkan bonepathologyinmultiplemyelomadiagnosisandtreatment |