Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway
Hydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anticancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain unclear. This study aimed to explore the func...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Clinical and Translational Science |
| Online Access: | https://doi.org/10.1111/cts.12765 |
| _version_ | 1819118925952057344 |
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| author | Hongtao He Kuangyuan Qiao Chao Wang Wuhan Yang Zhuo Xu Zhilei Zhang Yuming Jia Chong Zhang Li Peng |
| author_facet | Hongtao He Kuangyuan Qiao Chao Wang Wuhan Yang Zhuo Xu Zhilei Zhang Yuming Jia Chong Zhang Li Peng |
| author_sort | Hongtao He |
| collection | DOAJ |
| description | Hydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anticancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain unclear. This study aimed to explore the function and underlying mechanisms of HZC on HCC cells, which may involve the p38 mitogen activated protein kinase (MAPK) pathway. HZC was first purified and identified. HepG2 cells were then subjected to treatment with HZC or CUR of different concentrations and p38 MAPK signaling inhibitor (SB203580) to verify their effects on HCC cell apoptosis and proliferation. Furthermore, the functional relevance between HZC and the p38 MAPK pathway in HCC was examined. It was observed that 40 μM HZC exhibited the best pro‐apoptosis effect in HCC cells. HZC was found to inhibit HCC cell proliferation and promote apoptosis, the effect of which was stronger than 5‐fluorouracil (5‐FU). More importantly, the anti‐oncogenic effect of HZC and 5‐FU was implicated with activation of the p38 MAPK pathway. In vivo experimental results showed that HZC inhibited tumor growth more effectively than 5‐FU through the p38 MAPK pathway. These results provide evidence that HZC exerted anti‐oncogenic and pro‐apoptosis effects in HCC cells through activation of the p38 MAPK pathway. |
| first_indexed | 2024-12-22T05:56:38Z |
| format | Article |
| id | doaj.art-932eaba947914beb9768df62c764b2c1 |
| institution | Directory Open Access Journal |
| issn | 1752-8054 1752-8062 |
| language | English |
| last_indexed | 2024-12-22T05:56:38Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Science |
| spelling | doaj.art-932eaba947914beb9768df62c764b2c12022-12-21T18:36:41ZengWileyClinical and Translational Science1752-80541752-80622021-09-011452075208410.1111/cts.12765Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK PathwayHongtao He0Kuangyuan Qiao1Chao Wang2Wuhan Yang3Zhuo Xu4Zhilei Zhang5Yuming Jia6Chong Zhang7Li Peng8Department of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaBasic Medical College of Hebei Medical University Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaDepartment of Hepatobiliary Surgery Fourth Hospital of Hebei Medical University Tumor Hospital of Hebei Province Shijiazhuang ChinaHydrazinocurcumin (HZC), a synthetic derivative of curcumin (CUR), has been documented to show anticancer potential in impeding tumor growth in several cancers, including hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms remain unclear. This study aimed to explore the function and underlying mechanisms of HZC on HCC cells, which may involve the p38 mitogen activated protein kinase (MAPK) pathway. HZC was first purified and identified. HepG2 cells were then subjected to treatment with HZC or CUR of different concentrations and p38 MAPK signaling inhibitor (SB203580) to verify their effects on HCC cell apoptosis and proliferation. Furthermore, the functional relevance between HZC and the p38 MAPK pathway in HCC was examined. It was observed that 40 μM HZC exhibited the best pro‐apoptosis effect in HCC cells. HZC was found to inhibit HCC cell proliferation and promote apoptosis, the effect of which was stronger than 5‐fluorouracil (5‐FU). More importantly, the anti‐oncogenic effect of HZC and 5‐FU was implicated with activation of the p38 MAPK pathway. In vivo experimental results showed that HZC inhibited tumor growth more effectively than 5‐FU through the p38 MAPK pathway. These results provide evidence that HZC exerted anti‐oncogenic and pro‐apoptosis effects in HCC cells through activation of the p38 MAPK pathway.https://doi.org/10.1111/cts.12765 |
| spellingShingle | Hongtao He Kuangyuan Qiao Chao Wang Wuhan Yang Zhuo Xu Zhilei Zhang Yuming Jia Chong Zhang Li Peng Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway Clinical and Translational Science |
| title | Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway |
| title_full | Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway |
| title_fullStr | Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway |
| title_full_unstemmed | Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway |
| title_short | Hydrazinocurcumin Induces Apoptosis of Hepatocellular Carcinoma Cells Through the p38 MAPK Pathway |
| title_sort | hydrazinocurcumin induces apoptosis of hepatocellular carcinoma cells through the p38 mapk pathway |
| url | https://doi.org/10.1111/cts.12765 |
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