Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease
Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.746300/full |
| _version_ | 1818826131981205504 |
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| author | Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov |
| author_facet | Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov |
| author_sort | Elena Kutumova |
| collection | DOAJ |
| description | Here we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software. |
| first_indexed | 2024-12-19T00:22:47Z |
| format | Article |
| id | doaj.art-932ec238dd0f45d79f5c4262de1f5729 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T00:22:47Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-932ec238dd0f45d79f5c4262de1f57292022-12-21T20:45:27ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-11-011210.3389/fphys.2021.746300746300Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and DiseaseElena Kutumova0Elena Kutumova1Elena Kutumova2Ilya Kiselev3Ilya Kiselev4Ilya Kiselev5Ruslan Sharipov6Ruslan Sharipov7Ruslan Sharipov8Ruslan Sharipov9Galina Lifshits10Fedor Kolpakov11Fedor Kolpakov12Fedor Kolpakov13Department of Computational Biology, Sirius University of Science and Technology, Sochi, RussiaLaboratory of Bioinformatics, Federal Research Center for Information and Computational Technologies, Novosibirsk, RussiaBiosoft.Ru, Ltd., Novosibirsk, RussiaDepartment of Computational Biology, Sirius University of Science and Technology, Sochi, RussiaLaboratory of Bioinformatics, Federal Research Center for Information and Computational Technologies, Novosibirsk, RussiaBiosoft.Ru, Ltd., Novosibirsk, RussiaDepartment of Computational Biology, Sirius University of Science and Technology, Sochi, RussiaLaboratory of Bioinformatics, Federal Research Center for Information and Computational Technologies, Novosibirsk, RussiaBiosoft.Ru, Ltd., Novosibirsk, RussiaSpecialized Educational Scientific Center, Novosibirsk State University, Novosibirsk, RussiaLaboratory for Personalized Medicine, Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, RussiaDepartment of Computational Biology, Sirius University of Science and Technology, Sochi, RussiaLaboratory of Bioinformatics, Federal Research Center for Information and Computational Technologies, Novosibirsk, RussiaBiosoft.Ru, Ltd., Novosibirsk, RussiaHere we present a modular agent-based mathematical model of the human cardiovascular and renal systems. It integrates the previous models primarily developed by A. C. Guyton, F. Karaaslan, K. M. Hallow, and Y. V. Solodyannikov. We performed the model calibration to find an equilibrium state within the normal vital sign ranges for a healthy adult. We verified the model’s abilities to reproduce equilibrium states with abnormal physiological values related to different combinations of cardiovascular diseases (such as systemic hypertension, chronic heart failure, pulmonary hypertension, etc.). For the model creation and validation, we involved over 200 scientific studies covering known models of the human cardiovascular and renal functions, biosimulation platforms, and clinical measurements of physiological quantities in normal and pathological conditions. We compiled detailed documentation describing all equations, parameters and variables of the model with justification of all formulas and values. The model is implemented in BioUML and available in the web-version of the software.https://www.frontiersin.org/articles/10.3389/fphys.2021.746300/fullmathematical modelingagent-based modelmodular modelcardiovascular systemrenal systemblood pressure regulation |
| spellingShingle | Elena Kutumova Elena Kutumova Elena Kutumova Ilya Kiselev Ilya Kiselev Ilya Kiselev Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Ruslan Sharipov Galina Lifshits Fedor Kolpakov Fedor Kolpakov Fedor Kolpakov Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease Frontiers in Physiology mathematical modeling agent-based model modular model cardiovascular system renal system blood pressure regulation |
| title | Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_full | Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_fullStr | Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_full_unstemmed | Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_short | Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease |
| title_sort | thoroughly calibrated modular agent based model of the human cardiovascular and renal systems for blood pressure regulation in health and disease |
| topic | mathematical modeling agent-based model modular model cardiovascular system renal system blood pressure regulation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.746300/full |
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