Repression of factor VIII inhibitor development with apoptotic factor VIII-expressing embryonic stem cells

Repression of factor VIII inhibitor development with apoptotic factor VIII-expressing embryonic stem cells

Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to prevent the development of fVIII inhibitors. Mu...

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Bibliographic Details
Main Authors: Yoshihiko Sakurai, Shogo Kasuda, Kohei Tatsumi, Tomohiro Takeda, Junko Kato, Atsushi Kubo, Midori Shima
Format: Article
Language:English
Published: MDPI AG 2013-07-01
Series:Hematology Reports
Subjects:
hemophilia, fVIII inhibitors, prevention, embryonic stem cells, apoptosis
Online Access:http://www.pagepress.org/journals/index.php/hr/article/view/4461

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