Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies
Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5923 |
| _version_ | 1797531869643800576 |
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| author | Sarah Cunningham Holger Hackstein |
| author_facet | Sarah Cunningham Holger Hackstein |
| author_sort | Sarah Cunningham |
| collection | DOAJ |
| description | Human umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous properties have so far been applied for stem cell, mesenchymal stromal cell, and chimeric antigen receptor T cell therapies. However, UCB-derived professional antigen-presenting cells are increasingly being utilized in the context of immune tolerance and regenerative therapy. Here, we review the cell-specific characteristics as well as recent advancements in UCB-based cell therapies focusing on dendritic cells, monocytes, B lymphocytes, innate lymphoid cells, and macrophages. |
| first_indexed | 2024-03-10T10:50:57Z |
| format | Article |
| id | doaj.art-933046fb5e7b4fd382dfc4b65451155c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:50:57Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-933046fb5e7b4fd382dfc4b65451155c2023-11-21T22:16:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211592310.3390/ijms22115923Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell TherapiesSarah Cunningham0Holger Hackstein1Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Schwabachanlage 12, 91054 Erlangen, GermanyDepartment of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Schwabachanlage 12, 91054 Erlangen, GermanyHuman umbilical cord blood (UCB) represents a valuable source of hematopoietic stem cells, particularly for patients lacking a matching donor. UCB provides practical advantages, including a lower risk of graft-versus-host-disease and permissive human leukocyte antigen mismatching. These advantageous properties have so far been applied for stem cell, mesenchymal stromal cell, and chimeric antigen receptor T cell therapies. However, UCB-derived professional antigen-presenting cells are increasingly being utilized in the context of immune tolerance and regenerative therapy. Here, we review the cell-specific characteristics as well as recent advancements in UCB-based cell therapies focusing on dendritic cells, monocytes, B lymphocytes, innate lymphoid cells, and macrophages.https://www.mdpi.com/1422-0067/22/11/5923umbilical cord bloodantigen presentationcell therapyimmune reconstitution |
| spellingShingle | Sarah Cunningham Holger Hackstein Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies International Journal of Molecular Sciences umbilical cord blood antigen presentation cell therapy immune reconstitution |
| title | Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies |
| title_full | Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies |
| title_fullStr | Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies |
| title_full_unstemmed | Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies |
| title_short | Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies |
| title_sort | cord blood derived professional antigen presenting cells functions and applications in current and prospective cell therapies |
| topic | umbilical cord blood antigen presentation cell therapy immune reconstitution |
| url | https://www.mdpi.com/1422-0067/22/11/5923 |
| work_keys_str_mv | AT sarahcunningham cordbloodderivedprofessionalantigenpresentingcellsfunctionsandapplicationsincurrentandprospectivecelltherapies AT holgerhackstein cordbloodderivedprofessionalantigenpresentingcellsfunctionsandapplicationsincurrentandprospectivecelltherapies |