Genetic and Epigenetic Alterations of <i>CDH1</i> Regulatory Regions in Hereditary and Sporadic Gastric Cancer

Genetic and Epigenetic Alterations of <i>CDH1</i> Regulatory Regions in Hereditary and Sporadic Gastric Cancer

E-cadherin is a key player in gastric cancer (GC) and germline alterations of <i>CDH1</i>, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation of <i>CDH1</i>...

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Bibliographic Details
Main Authors: Gianluca Tedaldi, Chiara Molinari, Celina São José, Rita Barbosa-Matos, Ana André, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Luca Saragoni, Paolo Morgagni, Francesca Rebuzzi, Matteo Canale, Sara Pignatta, Elisa Ferracci, Giovanni Martinelli, Guglielmina Nadia Ranzani, Carla Oliveira, Daniele Calistri, Paola Ulivi
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceuticals
Subjects:
gastric cancer
<i>CDH1</i> gene
DNA methylation
regulatory regions
genetic predisposition
Next-Generation Sequencing
Online Access:https://www.mdpi.com/1424-8247/14/5/457

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https://www.mdpi.com/1424-8247/14/5/457

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