Synergistic effect of glutathione and IgG4 in immune evasion and the implication for cancer immunotherapy

Synergistic effect of glutathione and IgG4 in immune evasion and the implication for cancer immunotherapy

Background: We recently reported a novel IgG4-centered immune evasion mechanism in cancer, and this was achieved mostly through the Fc-Fc reaction of increased IgG4 to cancer-bound IgG in cancer microenvironment. The mechanism was suggested to be related to cancer hyperprogressive disease (HPD) whic...

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Bibliographic Details
Main Authors:	Weifeng Zhang, Yan Quan, Xiaonan Ma, Liting Zeng, Jirui Li, Shuqi Chen, Meng Su, Liangli Hong, Penghao Li, Hui Wang, Qian Xu, Chanyuan Zhao, Xiaoqing Zhu, Yiqun Geng, Xiaomiao Yan, Zheng Fang, Muwang Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	Redox Biology
Subjects:	Immunoglobulin G4 Glutathione Immunosuppression Immune evasion Hyperprogressive disease Immunotherapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723000095

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