Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration
BackgroundStressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.ObjectivesThe objectives for this study were to estimate plasma pharmacokinetic parame...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.968973/full |
| _version_ | 1811200054135881728 |
|---|---|
| author | Rachel Fladung Joe S. Smith Joe S. Smith Melissa T. Hines Windy Michelle Soto-Gonzalez Bryanna Fayne Rebecca R. Rahn Olivia Grace Escher Lainey Harvill Joan Bergman Jessica D. Garcia Amanda Jo Kreuder Sherry Cox |
| author_facet | Rachel Fladung Joe S. Smith Joe S. Smith Melissa T. Hines Windy Michelle Soto-Gonzalez Bryanna Fayne Rebecca R. Rahn Olivia Grace Escher Lainey Harvill Joan Bergman Jessica D. Garcia Amanda Jo Kreuder Sherry Cox |
| author_sort | Rachel Fladung |
| collection | DOAJ |
| description | BackgroundStressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.ObjectivesThe objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.Materials and methodsEsomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. Plasma samples were collected over 36 h and analyzed via reverse phase HPLC to determine concentrations of esomeprazole and esomeprazole sulfone. Pharmacokinetic parameters were derived via non-compartmental analysis.ResultsFollowing IV administration, mean values for plasma clearance (Cl), elimination half-life [T1/2 (λz)], C0, and volume of distribution (Vz) of esomeprazole were estimated at 24.9 mL/min/kg, 6 min, 2.324 μg/mL, and 0.23 L/kg, respectively. After SC administration elimination half-life, maximum concentration (Cmax) and time to maximum concentration (Tmax) of esomeprazole were estimated at 29 min, 1.038 μg/mL, and 22 minutes respectively. Maximum concentrations of the sulfone metabolite were 32 and 18 ng/mL after IV and SC administration.ConclusionEsomeprazole was rapidly eliminated from plasma after both IV and SC injection in goats. The elimination half-life in goats appears to be shorter than reported in dogs, as well as less than that reported for pantoprazole in goats. The sulfone metabolite was detected and also rapidly eliminated from the plasma after both IV and SC administration. Additional pharmacodynamic investigations are needed to determine the efficacy of esomeprazole on abomasal (gastric) acid suppression in goats and could include larger doses or additional routes of administration. |
| first_indexed | 2024-04-12T01:58:12Z |
| format | Article |
| id | doaj.art-9332a9b36c70418c81494d7e572c63cf |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T01:58:12Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-9332a9b36c70418c81494d7e572c63cf2022-12-22T03:52:45ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-12-01910.3389/fvets.2022.968973968973Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administrationRachel Fladung0Joe S. Smith1Joe S. Smith2Melissa T. Hines3Windy Michelle Soto-Gonzalez4Bryanna Fayne5Rebecca R. Rahn6Olivia Grace Escher7Lainey Harvill8Joan Bergman9Jessica D. Garcia10Amanda Jo Kreuder11Sherry Cox12Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesBiomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesBiomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesLarge Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesVeterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United StatesBiomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Knoxville, TN, United StatesBackgroundStressed and hospitalized goats are at risk of developing abomasal (gastric) ulceration, but there is a paucity of pharmacokinetic studies for proton pump inhibiting drugs, such as, esomeprazole in goats.ObjectivesThe objectives for this study were to estimate plasma pharmacokinetic parameters for esomeprazole in adult goats after intravenous (IV) and subcutaneous (SQ) administration. A secondary objective was to describe the plasma kinetics of the metabolite esomeprazole sulfone after IV and SC administration in goats.Materials and methodsEsomeprazole was administered to 5 adult goats in a crossover study at doses of 1 mg/kg IV or 2 mg/kg SC. Plasma samples were collected over 36 h and analyzed via reverse phase HPLC to determine concentrations of esomeprazole and esomeprazole sulfone. Pharmacokinetic parameters were derived via non-compartmental analysis.ResultsFollowing IV administration, mean values for plasma clearance (Cl), elimination half-life [T1/2 (λz)], C0, and volume of distribution (Vz) of esomeprazole were estimated at 24.9 mL/min/kg, 6 min, 2.324 μg/mL, and 0.23 L/kg, respectively. After SC administration elimination half-life, maximum concentration (Cmax) and time to maximum concentration (Tmax) of esomeprazole were estimated at 29 min, 1.038 μg/mL, and 22 minutes respectively. Maximum concentrations of the sulfone metabolite were 32 and 18 ng/mL after IV and SC administration.ConclusionEsomeprazole was rapidly eliminated from plasma after both IV and SC injection in goats. The elimination half-life in goats appears to be shorter than reported in dogs, as well as less than that reported for pantoprazole in goats. The sulfone metabolite was detected and also rapidly eliminated from the plasma after both IV and SC administration. Additional pharmacodynamic investigations are needed to determine the efficacy of esomeprazole on abomasal (gastric) acid suppression in goats and could include larger doses or additional routes of administration.https://www.frontiersin.org/articles/10.3389/fvets.2022.968973/fullproton pump inhibitorulcergoat (Capra aegagrus hircus)pharmacokineticsesomeprazoleruminant |
| spellingShingle | Rachel Fladung Joe S. Smith Joe S. Smith Melissa T. Hines Windy Michelle Soto-Gonzalez Bryanna Fayne Rebecca R. Rahn Olivia Grace Escher Lainey Harvill Joan Bergman Jessica D. Garcia Amanda Jo Kreuder Sherry Cox Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration Frontiers in Veterinary Science proton pump inhibitor ulcer goat (Capra aegagrus hircus) pharmacokinetics esomeprazole ruminant |
| title | Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration |
| title_full | Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration |
| title_fullStr | Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration |
| title_full_unstemmed | Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration |
| title_short | Pharmacokinetics of esomeprazole in goats (Capra aegagrus hircus) after intravenous and subcutaneous administration |
| title_sort | pharmacokinetics of esomeprazole in goats capra aegagrus hircus after intravenous and subcutaneous administration |
| topic | proton pump inhibitor ulcer goat (Capra aegagrus hircus) pharmacokinetics esomeprazole ruminant |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.968973/full |
| work_keys_str_mv | AT rachelfladung pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT joessmith pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT joessmith pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT melissathines pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT windymichellesotogonzalez pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT bryannafayne pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT rebeccarrahn pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT oliviagraceescher pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT laineyharvill pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT joanbergman pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT jessicadgarcia pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT amandajokreuder pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration AT sherrycox pharmacokineticsofesomeprazoleingoatscapraaegagrushircusafterintravenousandsubcutaneousadministration |