Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway

Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 Pathway

<i>Background and Objectives</i>: Damage to normal bone tissue following therapeutic irradiation (IR) represents a significant concern, as IR-induced bone microenvironment disruption can cause bone loss and create a more favorable environment for tumor metastases. The aim of the present...

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Bibliographic Details
Main Authors: Yuyang Wang, Li Ren, Linshan Xu, Jianping Wang, Jianglong Zhai, Guoying Zhu
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Medicina
Subjects:
radiation
bone microenvironment
osteocyte
stimulator of interferon genes (STING)
senescence-associated secretory phenotype (SASP)
osteoclastogenesis
Online Access:https://www.mdpi.com/1648-9144/59/7/1316

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