Leptin’s concentration in tears and dry eye: a clinical observational study
AIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2021-01-01
|
| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/en_publish/2021/1/20210112.pdf |
| _version_ | 1819279013419417600 |
|---|---|
| author | Ran Hao Yan Liu Xue-Min Li |
| author_facet | Ran Hao Yan Liu Xue-Min Li |
| author_sort | Ran Hao |
| collection | DOAJ |
| description | AIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration measuring. Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear break up time (TBUT), cornea fluorescein staining, Schirmer test (ST) and impression cytology (IC) were assessed. Leptin concentration in tears of dry eye patients and healthy controls, and its correlation with clinical features of dry eye disease (DED) were analyzed. RESULTS: Age, body mass index (BMI), OSDI scores and cornea fluorescein staining scores showed a negative correlation with leptin concentration in tears (r=-0.340, P=0.001; r=-0.332, P=0.001; r=-0.258, P=0.011; r=-0.424, P<0.001, respectively). ST showed positive correlation with leptin concentration in tears (r=0.206, P=0.045). No significant difference was observed in leptin concentration between dry eye patients and controls (P=0.682). Multivariate linear regression analysis revealed that dry eye, OSDI, corneal fluorescein staining scores and ST correlated with leptin concentration in tears. CONCLUSION: This is the first study measuring leptin concentration in tears. The correlation between leptin concentration and DED symptoms and signs reveal that leptin level correlated with the dry eye, potentially contributing to repair of ocular damage and dry eye improvement. |
| first_indexed | 2024-12-24T00:21:09Z |
| format | Article |
| id | doaj.art-9332c4ee8eb2424c903386037e774df8 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-24T00:21:09Z |
| publishDate | 2021-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-9332c4ee8eb2424c903386037e774df82022-12-21T17:24:36ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982021-01-01141838810.18240/ijo.2021.01.1220210112Leptin’s concentration in tears and dry eye: a clinical observational studyRan Hao0Yan Liu1Xue-Min Li2Xue-Min Li. Peking University Third Hospital, No. 49, North Garden Street, Beijing 100191, China. 13911254862@163.comDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, ChinaAIM: To investigate the concentration of leptin in tears and its correlation with dry eye symptoms and signs. METHODS: The study enrolled individuals (n=39) responding to an advertising or dry eye patients (n=58) from the Ophthalmology Department. Tear samples were collected for leptin concentration measuring. Ocular Surface Disease Index (OSDI), tear meniscus height (TMH), tear break up time (TBUT), cornea fluorescein staining, Schirmer test (ST) and impression cytology (IC) were assessed. Leptin concentration in tears of dry eye patients and healthy controls, and its correlation with clinical features of dry eye disease (DED) were analyzed. RESULTS: Age, body mass index (BMI), OSDI scores and cornea fluorescein staining scores showed a negative correlation with leptin concentration in tears (r=-0.340, P=0.001; r=-0.332, P=0.001; r=-0.258, P=0.011; r=-0.424, P<0.001, respectively). ST showed positive correlation with leptin concentration in tears (r=0.206, P=0.045). No significant difference was observed in leptin concentration between dry eye patients and controls (P=0.682). Multivariate linear regression analysis revealed that dry eye, OSDI, corneal fluorescein staining scores and ST correlated with leptin concentration in tears. CONCLUSION: This is the first study measuring leptin concentration in tears. The correlation between leptin concentration and DED symptoms and signs reveal that leptin level correlated with the dry eye, potentially contributing to repair of ocular damage and dry eye improvement.http://ies.ijo.cn/en_publish/2021/1/20210112.pdfdry eye diseaseleptinocular surface inflammationwound healing |
| spellingShingle | Ran Hao Yan Liu Xue-Min Li Leptin’s concentration in tears and dry eye: a clinical observational study International Journal of Ophthalmology dry eye disease leptin ocular surface inflammation wound healing |
| title | Leptin’s concentration in tears and dry eye: a clinical observational study |
| title_full | Leptin’s concentration in tears and dry eye: a clinical observational study |
| title_fullStr | Leptin’s concentration in tears and dry eye: a clinical observational study |
| title_full_unstemmed | Leptin’s concentration in tears and dry eye: a clinical observational study |
| title_short | Leptin’s concentration in tears and dry eye: a clinical observational study |
| title_sort | leptin s concentration in tears and dry eye a clinical observational study |
| topic | dry eye disease leptin ocular surface inflammation wound healing |
| url | http://ies.ijo.cn/en_publish/2021/1/20210112.pdf |
| work_keys_str_mv | AT ranhao leptinsconcentrationintearsanddryeyeaclinicalobservationalstudy AT yanliu leptinsconcentrationintearsanddryeyeaclinicalobservationalstudy AT xueminli leptinsconcentrationintearsanddryeyeaclinicalobservationalstudy |