Right atrial mechanics provide useful insight in pediatric pulmonary hypertension
Right atrial (RA) mechanics have been studied infrequently in children in the past due to technical constraints. With the advent of strain imaging, RA physiology can now be studied in greater detail. The principal aim of this study was to describe functional changes in right heart mechanics of child...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045893218754852 |
| _version_ | 1817977937998118912 |
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| author | Kyle D. Hope Renzo José Carlos Calderón Anyosa Yan Wang Andrea E. Montero Tomoyuki Sato Brian D. Hanna Anirban Banerjee |
| author_facet | Kyle D. Hope Renzo José Carlos Calderón Anyosa Yan Wang Andrea E. Montero Tomoyuki Sato Brian D. Hanna Anirban Banerjee |
| author_sort | Kyle D. Hope |
| collection | DOAJ |
| description | Right atrial (RA) mechanics have been studied infrequently in children in the past due to technical constraints. With the advent of strain imaging, RA physiology can now be studied in greater detail. The principal aim of this study was to describe functional changes in right heart mechanics of children with idiopathic pulmonary arterial hypertension (PAH), by using new applications of RA strain. In this retrospective study, we evaluated RA mechanics of 20 patients (age range = 3–23 years) with PAH and 18 control patients. RA longitudinal strain (RALS) and longitudinal displacement (LD) were calculated by speckle-tracking echocardiography. RALS was plotted against LD, producing a characteristic strain-displacement (S-D) loop. Standard indices of right heart function and right heart catheterization data were obtained. Patients were clinically subdivided into “compensated” and “decompensated” PAH. A chart review was performed to identify patients who subsequently developed adverse outcomes, including death, awaiting or received lung and/or heart transplantation. RALS was significantly lower in decompensated PAH compared with both controls and compensated PAH. Area enclosed by S-D loops differed significantly between the compensated and decompensated PAH subgroups (5.33 [3.90–9.44] versus 1.83 [1.17–2.36], P < 0.05). S-D loop area and RALS possessed high sensitivity and specificity compared to other parameters for identifying children with PAH who subsequently developed adverse outcomes. In particular, their sensitivities and specificities were greatly superior compared to those of tricuspid annular plane systolic excursion (TAPSE). RALS may represent a useful metric for assessing right ventricular (RV) dysfunction. S-D loops, composed over an entire cardiac cycle, may present useful, composite information regarding both systolic and diastolic right heart function. RA mechanics may serve as useful tools for identifying patients with more severe PAH, who are at risk for future adverse outcomes associated with RV failure. |
| first_indexed | 2024-04-13T22:23:54Z |
| format | Article |
| id | doaj.art-93348daa67164e1285aa9713d61a7fe0 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-13T22:23:54Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-93348daa67164e1285aa9713d61a7fe02022-12-22T02:27:08ZengWileyPulmonary Circulation2045-89402018-01-01810.1177/2045893218754852Right atrial mechanics provide useful insight in pediatric pulmonary hypertensionKyle D. HopeRenzo José Carlos Calderón AnyosaYan WangAndrea E. MonteroTomoyuki SatoBrian D. HannaAnirban BanerjeeRight atrial (RA) mechanics have been studied infrequently in children in the past due to technical constraints. With the advent of strain imaging, RA physiology can now be studied in greater detail. The principal aim of this study was to describe functional changes in right heart mechanics of children with idiopathic pulmonary arterial hypertension (PAH), by using new applications of RA strain. In this retrospective study, we evaluated RA mechanics of 20 patients (age range = 3–23 years) with PAH and 18 control patients. RA longitudinal strain (RALS) and longitudinal displacement (LD) were calculated by speckle-tracking echocardiography. RALS was plotted against LD, producing a characteristic strain-displacement (S-D) loop. Standard indices of right heart function and right heart catheterization data were obtained. Patients were clinically subdivided into “compensated” and “decompensated” PAH. A chart review was performed to identify patients who subsequently developed adverse outcomes, including death, awaiting or received lung and/or heart transplantation. RALS was significantly lower in decompensated PAH compared with both controls and compensated PAH. Area enclosed by S-D loops differed significantly between the compensated and decompensated PAH subgroups (5.33 [3.90–9.44] versus 1.83 [1.17–2.36], P < 0.05). S-D loop area and RALS possessed high sensitivity and specificity compared to other parameters for identifying children with PAH who subsequently developed adverse outcomes. In particular, their sensitivities and specificities were greatly superior compared to those of tricuspid annular plane systolic excursion (TAPSE). RALS may represent a useful metric for assessing right ventricular (RV) dysfunction. S-D loops, composed over an entire cardiac cycle, may present useful, composite information regarding both systolic and diastolic right heart function. RA mechanics may serve as useful tools for identifying patients with more severe PAH, who are at risk for future adverse outcomes associated with RV failure.https://doi.org/10.1177/2045893218754852 |
| spellingShingle | Kyle D. Hope Renzo José Carlos Calderón Anyosa Yan Wang Andrea E. Montero Tomoyuki Sato Brian D. Hanna Anirban Banerjee Right atrial mechanics provide useful insight in pediatric pulmonary hypertension Pulmonary Circulation |
| title | Right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| title_full | Right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| title_fullStr | Right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| title_full_unstemmed | Right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| title_short | Right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| title_sort | right atrial mechanics provide useful insight in pediatric pulmonary hypertension |
| url | https://doi.org/10.1177/2045893218754852 |
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