VEGF Signaling in Neurological Disorders
Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/19/1/275 |
| _version_ | 1811232489468854272 |
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| author | Joon W. Shim Joseph R. Madsen |
| author_facet | Joon W. Shim Joseph R. Madsen |
| author_sort | Joon W. Shim |
| collection | DOAJ |
| description | Vascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, we discovered that a heparin binding epidermal growth factor like growth factor (HB-EGF)—a class of EGF receptor (EGFR) family ligands—contributes to the development of hydrocephalus with subarachnoid hemorrhage through activation of VEGF signaling. The objective of this review is to entail a recent update on causes of death due to neurological disorders involving cerebrovascular and age-related neurological conditions and to understand the mechanism by which angiogenesis-dependent pathological events can be treated with VEGF antagonisms. The Global Burden of Disease study indicates that cancer and cardiovascular disease including ischemic and hemorrhagic stroke are two leading causes of death worldwide. The literature suggests that VEGF signaling in ischemic brains highlights the importance of concentration, timing, and alternate route of modulating VEGF signaling pathway. Molecular targets distinguishing two distinct pathways of VEGF signaling may provide novel therapies for the treatment of neurological disorders and for maintaining lower mortality due to these conditions. |
| first_indexed | 2024-04-12T11:03:41Z |
| format | Article |
| id | doaj.art-93352c37d41541e18fb5ea23e6daef8e |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T11:03:41Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-93352c37d41541e18fb5ea23e6daef8e2022-12-22T03:35:52ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-01-0119127510.3390/ijms19010275ijms19010275VEGF Signaling in Neurological DisordersJoon W. Shim0Joseph R. Madsen1Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USADepartment of Neurosurgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USAVascular endothelial growth factor (VEGF) is a potent growth factor playing diverse roles in vasculogenesis and angiogenesis. In the brain, VEGF mediates angiogenesis, neural migration and neuroprotection. As a permeability factor, excessive VEGF disrupts intracellular barriers, increases leakage of the choroid plexus endothelia, evokes edema, and activates the inflammatory pathway. Recently, we discovered that a heparin binding epidermal growth factor like growth factor (HB-EGF)—a class of EGF receptor (EGFR) family ligands—contributes to the development of hydrocephalus with subarachnoid hemorrhage through activation of VEGF signaling. The objective of this review is to entail a recent update on causes of death due to neurological disorders involving cerebrovascular and age-related neurological conditions and to understand the mechanism by which angiogenesis-dependent pathological events can be treated with VEGF antagonisms. The Global Burden of Disease study indicates that cancer and cardiovascular disease including ischemic and hemorrhagic stroke are two leading causes of death worldwide. The literature suggests that VEGF signaling in ischemic brains highlights the importance of concentration, timing, and alternate route of modulating VEGF signaling pathway. Molecular targets distinguishing two distinct pathways of VEGF signaling may provide novel therapies for the treatment of neurological disorders and for maintaining lower mortality due to these conditions.http://www.mdpi.com/1422-0067/19/1/275vascular endothelial growth factorcerebrovascular diseasestrokehydrocephalusneurological disorders |
| spellingShingle | Joon W. Shim Joseph R. Madsen VEGF Signaling in Neurological Disorders International Journal of Molecular Sciences vascular endothelial growth factor cerebrovascular disease stroke hydrocephalus neurological disorders |
| title | VEGF Signaling in Neurological Disorders |
| title_full | VEGF Signaling in Neurological Disorders |
| title_fullStr | VEGF Signaling in Neurological Disorders |
| title_full_unstemmed | VEGF Signaling in Neurological Disorders |
| title_short | VEGF Signaling in Neurological Disorders |
| title_sort | vegf signaling in neurological disorders |
| topic | vascular endothelial growth factor cerebrovascular disease stroke hydrocephalus neurological disorders |
| url | http://www.mdpi.com/1422-0067/19/1/275 |
| work_keys_str_mv | AT joonwshim vegfsignalinginneurologicaldisorders AT josephrmadsen vegfsignalinginneurologicaldisorders |