The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents
ObjectiveTo evaluate the prevalence of hyperglycemia and dyslipidemia among different body composition and investigate the associations of body composition indicators, especially the muscle mass, with glucose and lipids metabolism in children and adolescents.MethodsThis nationwide cross-sectional st...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.976998/full |
| _version_ | 1828111103593283584 |
|---|---|
| author | Liwang Gao Hong Cheng Yinkun Yan Junting Liu Xinying Shan Xi Wang Jie Mi Jie Mi |
| author_facet | Liwang Gao Hong Cheng Yinkun Yan Junting Liu Xinying Shan Xi Wang Jie Mi Jie Mi |
| author_sort | Liwang Gao |
| collection | DOAJ |
| description | ObjectiveTo evaluate the prevalence of hyperglycemia and dyslipidemia among different body composition and investigate the associations of body composition indicators, especially the muscle mass, with glucose and lipids metabolism in children and adolescents.MethodsThis nationwide cross-sectional study included 8,905 children and adolescents aged 6 to 18 years. All participants underwent dual-energy x-ray absorptiometry and their blood-concentrated glucose and lipids (including TC, TG, LDL-C and HDL-c) were measured. Mixed model, hierarchical analysis, and piecewise regression were used to study the effect of body composition indicators, especially the muscle mass, on glucose and lipids metabolism.ResultsThe greatest prevalence of high total cholesterol (TC, 6.9% and 6.9%) and high triglyceride (22.3% and 6.6%) was found in both boys and girls with high muscle mass and high fat mass, and girls with high muscle mass and high fat mass also had the highest prevalence of hyperglycemia (7.1%). After fat stratification, higher muscle mass was associated with lower odds of hyperglycemia (OR = 0.62; 95%CI: 0.46,0.84; P = 0.002) and muscle mass was inversely associated with TC (β = −0.07; 95%CI: -0.12,-0.03; P < 0.001) in boys with normal fat mass, but high muscle mass was not significantly associated with hyperglycemia and TC in high-fat-mass group (P = 0.368 and 0.372).ConclusionsThe body composition phenotype of high muscle and high fat mass have the highest prevalence of dysglycemia and dyslipidemia. Higher muscle mass was associated with a lower risk of hyperglycemia and TC levels in individuals only with normal fat mass. |
| first_indexed | 2024-04-11T11:29:34Z |
| format | Article |
| id | doaj.art-933924c80a3145e1800ae4401e238c39 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T11:29:34Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-933924c80a3145e1800ae4401e238c392022-12-22T04:26:12ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.976998976998The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescentsLiwang Gao0Hong Cheng1Yinkun Yan2Junting Liu3Xinying Shan4Xi Wang5Jie Mi6Jie Mi7Center for Non-communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, ChinaCenter for Non-communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, ChinaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, ChinaCenter for Non-communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaCenter for Non-communicable Disease Management, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Epidemiology, Capital Institute of Pediatrics, Beijing, ChinaObjectiveTo evaluate the prevalence of hyperglycemia and dyslipidemia among different body composition and investigate the associations of body composition indicators, especially the muscle mass, with glucose and lipids metabolism in children and adolescents.MethodsThis nationwide cross-sectional study included 8,905 children and adolescents aged 6 to 18 years. All participants underwent dual-energy x-ray absorptiometry and their blood-concentrated glucose and lipids (including TC, TG, LDL-C and HDL-c) were measured. Mixed model, hierarchical analysis, and piecewise regression were used to study the effect of body composition indicators, especially the muscle mass, on glucose and lipids metabolism.ResultsThe greatest prevalence of high total cholesterol (TC, 6.9% and 6.9%) and high triglyceride (22.3% and 6.6%) was found in both boys and girls with high muscle mass and high fat mass, and girls with high muscle mass and high fat mass also had the highest prevalence of hyperglycemia (7.1%). After fat stratification, higher muscle mass was associated with lower odds of hyperglycemia (OR = 0.62; 95%CI: 0.46,0.84; P = 0.002) and muscle mass was inversely associated with TC (β = −0.07; 95%CI: -0.12,-0.03; P < 0.001) in boys with normal fat mass, but high muscle mass was not significantly associated with hyperglycemia and TC in high-fat-mass group (P = 0.368 and 0.372).ConclusionsThe body composition phenotype of high muscle and high fat mass have the highest prevalence of dysglycemia and dyslipidemia. Higher muscle mass was associated with a lower risk of hyperglycemia and TC levels in individuals only with normal fat mass.https://www.frontiersin.org/articles/10.3389/fendo.2022.976998/fullobesitymuscle mass and fat massglucoselipidschildren |
| spellingShingle | Liwang Gao Hong Cheng Yinkun Yan Junting Liu Xinying Shan Xi Wang Jie Mi Jie Mi The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents Frontiers in Endocrinology obesity muscle mass and fat mass glucose lipids children |
| title | The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| title_full | The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| title_fullStr | The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| title_full_unstemmed | The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| title_short | The associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| title_sort | associations of muscle mass with glucose and lipid metabolism are influenced by body fat accumulation in children and adolescents |
| topic | obesity muscle mass and fat mass glucose lipids children |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.976998/full |
| work_keys_str_mv | AT liwanggao theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT hongcheng theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT yinkunyan theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT juntingliu theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT xinyingshan theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT xiwang theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT jiemi theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT jiemi theassociationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT liwanggao associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT hongcheng associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT yinkunyan associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT juntingliu associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT xinyingshan associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT xiwang associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT jiemi associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents AT jiemi associationsofmusclemasswithglucoseandlipidmetabolismareinfluencedbybodyfataccumulationinchildrenandadolescents |