ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA
The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2016-03-01
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| Series: | Research Results in Pharmacology |
| Subjects: | |
| Online Access: | https://rrpharmacology.pensoft.net/article/31033/download/pdf/ |
| _version_ | 1797429160616919040 |
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| author | Vladimir Provotorov Mikhail Korokin Mikhail Pokrovskii Sergej Povetkin Galina Lazareva Aleksandr Stepchenko Natalya Bystrova |
| author_facet | Vladimir Provotorov Mikhail Korokin Mikhail Pokrovskii Sergej Povetkin Galina Lazareva Aleksandr Stepchenko Natalya Bystrova |
| author_sort | Vladimir Provotorov |
| collection | DOAJ |
| description | The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows on the background of a significant reduction in homocysteine concentrations normalizing the endothelial dysfunction coefficient and the parameters of maximum left ventricular pressure in response to intravenous administration of adrenaline. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7. |
| first_indexed | 2024-03-09T09:09:12Z |
| format | Article |
| id | doaj.art-933986da318e4d79a1804c53f7aef71f |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:09:12Z |
| publishDate | 2016-03-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-933986da318e4d79a1804c53f7aef71f2023-12-02T09:26:15ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2016-03-0121161910.18413/2313-8971-2016-2-1-16-1931033ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIAVladimir ProvotorovMikhail KorokinMikhail PokrovskiiSergej PovetkinGalina LazarevaAleksandr StepchenkoNatalya BystrovaThe endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose of 3 g/kg were studied. It was shown that the combined use of vitamin B6 and folic acid allows on the background of a significant reduction in homocysteine concentrations normalizing the endothelial dysfunction coefficient and the parameters of maximum left ventricular pressure in response to intravenous administration of adrenaline. The research was partially supported by the grant of the President of the Russian Federation №MD-4711.2015.7.https://rrpharmacology.pensoft.net/article/31033/download/pdf/endothelial dysfunctionfolic acidvitamin B6h |
| spellingShingle | Vladimir Provotorov Mikhail Korokin Mikhail Pokrovskii Sergej Povetkin Galina Lazareva Aleksandr Stepchenko Natalya Bystrova ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA Research Results in Pharmacology endothelial dysfunction folic acid vitamin B6 h |
| title | ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA |
| title_full | ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA |
| title_fullStr | ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA |
| title_full_unstemmed | ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA |
| title_short | ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA |
| title_sort | endothelio and cardioprotective effects of vitamin в6 and folic acid in modelling methionine induced hyperhomocysteinemia |
| topic | endothelial dysfunction folic acid vitamin B6 h |
| url | https://rrpharmacology.pensoft.net/article/31033/download/pdf/ |
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