The Dysbiosis Triggered by First-Line Tuberculosis Antibiotics Fails to Reduce Their Bioavailability

The Dysbiosis Triggered by First-Line Tuberculosis Antibiotics Fails to Reduce Their Bioavailability

ABSTRACT Antituberculosis therapy (ATT) causes a rapid and distinct alteration in the composition of the intestinal microbiota that is long lasting in both mice and humans. This observation raised the question of whether such antibiotic-induced changes in the microbiome might affect the absorption o...

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Bibliographic Details
Main Authors: Sivaranjani Namasivayam, Matthew Zimmerman, Sandra Oland, Han Wang, Lara R. Mittereder, Véronique Dartois, Alan Sher
Format: Article
Language:English
Published: American Society for Microbiology 2023-04-01
Series:mBio
Subjects:
TB
antibiotics
microbiome
pharmacokinetics
Online Access:https://journals.asm.org/doi/10.1128/mbio.00353-23

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