Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy

Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy

The adaptor LAT plays a crucial role in the transduction of signals coming from the TCR/CD3 complex. Phosphorylation of some of its tyrosines generates recruitment sites for other cytosolic signaling molecules. Tyrosine 132 in human LAT is essential for PLC-γ activation and calcium influx generation...

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Bibliographic Details
Main Authors: Mikel M. Arbulo-Echevarria, Inmaculada Vico-Barranco, Isaac Narbona-Sánchez, Francisco García-Cózar, Arkadiusz Miazek, Enrique Aguado
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
LAT
TCR
phosphorylation
anergy
IL-2 (interleukin-2)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.561503/full

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