Placental Malaria: A New Insight into the Pathophysiology
Malaria in pregnancy poses a great health risk to mother and her fetus and results into complications, such as abortion, still birth, intra uterine growth retardation, and low birth weight. The heavy infiltration of Plasmodium falciparum-infected RBCs in the intervillous spaces of placenta seems to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmed.2017.00117/full |
| _version_ | 1811322926510637056 |
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| author | Lalita Sharma Geeta Shukla |
| author_facet | Lalita Sharma Geeta Shukla |
| author_sort | Lalita Sharma |
| collection | DOAJ |
| description | Malaria in pregnancy poses a great health risk to mother and her fetus and results into complications, such as abortion, still birth, intra uterine growth retardation, and low birth weight. The heavy infiltration of Plasmodium falciparum-infected RBCs in the intervillous spaces of placenta seems to be responsible for all the complications observed. Infected RBCs in the placenta cause an inflammatory environment with increase in inflammatory cells and cytokines which is deleterious to the placenta. Increased inflammatory responses in the infected placenta result into oxidative stress that in turn causes oxidative stress-induced placental cell death. Moreover, heat shock proteins that are produced in high concentration in stressed cells to combat the stress have been reported in fewer concentrations in malaria-infected placenta. Pathologies associated with placental malaria seems to be the effect of a change in immune status from antibody-mediated immune response to cell-mediated immune response resulting into excess inflammation, oxidative stress, apoptosis, and decreased heat shock protein expression. However, we also need to study other aspects of pathologies so that better drugs can be designed with new molecular targets. |
| first_indexed | 2024-04-13T13:43:28Z |
| format | Article |
| id | doaj.art-933a662dc7194b1aaf50d75867d4499d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T13:43:28Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-933a662dc7194b1aaf50d75867d4499d2022-12-22T02:44:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2017-07-01410.3389/fmed.2017.00117285923Placental Malaria: A New Insight into the PathophysiologyLalita Sharma0Geeta Shukla1Department of Microbiology, Panjab University, Chandigarh, IndiaDepartment of Microbiology, Panjab University, Chandigarh, IndiaMalaria in pregnancy poses a great health risk to mother and her fetus and results into complications, such as abortion, still birth, intra uterine growth retardation, and low birth weight. The heavy infiltration of Plasmodium falciparum-infected RBCs in the intervillous spaces of placenta seems to be responsible for all the complications observed. Infected RBCs in the placenta cause an inflammatory environment with increase in inflammatory cells and cytokines which is deleterious to the placenta. Increased inflammatory responses in the infected placenta result into oxidative stress that in turn causes oxidative stress-induced placental cell death. Moreover, heat shock proteins that are produced in high concentration in stressed cells to combat the stress have been reported in fewer concentrations in malaria-infected placenta. Pathologies associated with placental malaria seems to be the effect of a change in immune status from antibody-mediated immune response to cell-mediated immune response resulting into excess inflammation, oxidative stress, apoptosis, and decreased heat shock protein expression. However, we also need to study other aspects of pathologies so that better drugs can be designed with new molecular targets.http://journal.frontiersin.org/article/10.3389/fmed.2017.00117/fullmalariaplacentapregnancylow birth weightintra uterine growth retardation |
| spellingShingle | Lalita Sharma Geeta Shukla Placental Malaria: A New Insight into the Pathophysiology Frontiers in Medicine malaria placenta pregnancy low birth weight intra uterine growth retardation |
| title | Placental Malaria: A New Insight into the Pathophysiology |
| title_full | Placental Malaria: A New Insight into the Pathophysiology |
| title_fullStr | Placental Malaria: A New Insight into the Pathophysiology |
| title_full_unstemmed | Placental Malaria: A New Insight into the Pathophysiology |
| title_short | Placental Malaria: A New Insight into the Pathophysiology |
| title_sort | placental malaria a new insight into the pathophysiology |
| topic | malaria placenta pregnancy low birth weight intra uterine growth retardation |
| url | http://journal.frontiersin.org/article/10.3389/fmed.2017.00117/full |
| work_keys_str_mv | AT lalitasharma placentalmalariaanewinsightintothepathophysiology AT geetashukla placentalmalariaanewinsightintothepathophysiology |