Post-Operative Adhesions: A Comprehensive Review of Mechanisms
Post-surgical adhesions are common in almost all surgical areas and are associated with significant rates of morbidity, mortality, and increased healthcare costs, especially when a patient requires repeat operative interventions. Many groups have studied the mechanisms driving post-surgical adhesion...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/8/867 |
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| author | Ali Fatehi Hassanabad Anna N. Zarzycki Kristina Jeon Justin F. Deniset Paul W. M. Fedak |
| author_facet | Ali Fatehi Hassanabad Anna N. Zarzycki Kristina Jeon Justin F. Deniset Paul W. M. Fedak |
| author_sort | Ali Fatehi Hassanabad |
| collection | DOAJ |
| description | Post-surgical adhesions are common in almost all surgical areas and are associated with significant rates of morbidity, mortality, and increased healthcare costs, especially when a patient requires repeat operative interventions. Many groups have studied the mechanisms driving post-surgical adhesion formation. Despite continued advancements, we are yet to identify a prevailing mechanism. It is highly likely that post-operative adhesions have a multifactorial etiology. This complex pathophysiology, coupled with our incomplete understanding of the underlying pathways, has resulted in therapeutic options that have failed to demonstrate safety and efficacy on a consistent basis. The translation of findings from basic and preclinical research into robust clinical trials has also remained elusive. Herein, we present and contextualize the latest findings surrounding mechanisms that have been implicated in post-surgical adhesion formation. |
| first_indexed | 2024-03-10T08:59:36Z |
| format | Article |
| id | doaj.art-933d447429c441a5b2701b665281bd18 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:36Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-933d447429c441a5b2701b665281bd182023-11-22T06:51:15ZengMDPI AGBiomedicines2227-90592021-07-019886710.3390/biomedicines9080867Post-Operative Adhesions: A Comprehensive Review of MechanismsAli Fatehi Hassanabad0Anna N. Zarzycki1Kristina Jeon2Justin F. Deniset3Paul W. M. Fedak4Section of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, CanadaSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, CanadaDepartment of Anesthesiology and Pain Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2R7, CanadaSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, CanadaSection of Cardiac Surgery, Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 2N9, CanadaPost-surgical adhesions are common in almost all surgical areas and are associated with significant rates of morbidity, mortality, and increased healthcare costs, especially when a patient requires repeat operative interventions. Many groups have studied the mechanisms driving post-surgical adhesion formation. Despite continued advancements, we are yet to identify a prevailing mechanism. It is highly likely that post-operative adhesions have a multifactorial etiology. This complex pathophysiology, coupled with our incomplete understanding of the underlying pathways, has resulted in therapeutic options that have failed to demonstrate safety and efficacy on a consistent basis. The translation of findings from basic and preclinical research into robust clinical trials has also remained elusive. Herein, we present and contextualize the latest findings surrounding mechanisms that have been implicated in post-surgical adhesion formation.https://www.mdpi.com/2227-9059/9/8/867post-surgical adhesionsunderlying mechanismstranslational research |
| spellingShingle | Ali Fatehi Hassanabad Anna N. Zarzycki Kristina Jeon Justin F. Deniset Paul W. M. Fedak Post-Operative Adhesions: A Comprehensive Review of Mechanisms Biomedicines post-surgical adhesions underlying mechanisms translational research |
| title | Post-Operative Adhesions: A Comprehensive Review of Mechanisms |
| title_full | Post-Operative Adhesions: A Comprehensive Review of Mechanisms |
| title_fullStr | Post-Operative Adhesions: A Comprehensive Review of Mechanisms |
| title_full_unstemmed | Post-Operative Adhesions: A Comprehensive Review of Mechanisms |
| title_short | Post-Operative Adhesions: A Comprehensive Review of Mechanisms |
| title_sort | post operative adhesions a comprehensive review of mechanisms |
| topic | post-surgical adhesions underlying mechanisms translational research |
| url | https://www.mdpi.com/2227-9059/9/8/867 |
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