Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery
Study Design Prospective randomized, double-blind controlled trial. Purpose Here, we aim to compare the efficacy and safety of pain control between pre- and postoperative parecoxib administration in patients who have undergone major spine surgery. Overview of Literature Several studies have compared...
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| Format: | Article |
| Language: | English |
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Korean Spine Society
2018-10-01
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| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-2018-12-5-893.pdf |
| _version_ | 1818535585418051584 |
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| author | Rayakorn Moonla Adisorn Threetipayarak Chininthon Panpaisarn Nida Pattayaruk Unchana Kaewkam Nipawan Jumpalee Jatupong Panwilai |
| author_facet | Rayakorn Moonla Adisorn Threetipayarak Chininthon Panpaisarn Nida Pattayaruk Unchana Kaewkam Nipawan Jumpalee Jatupong Panwilai |
| author_sort | Rayakorn Moonla |
| collection | DOAJ |
| description | Study Design Prospective randomized, double-blind controlled trial. Purpose Here, we aim to compare the efficacy and safety of pain control between pre- and postoperative parecoxib administration in patients who have undergone major spine surgery. Overview of Literature Several studies have compared the efficacy of pre- and postoperative administration of parecoxib, which led to inconclusive results owing to variation in operative time. Preincisional parecoxib administration reduces inflammatory response in major spine surgery requiring longer operative time; however, it may not reduce pain as much as parecoxib administration immediately after surgery would. Methods Totally, 127 patients who underwent major spine surgery were randomly divided into three groups: pre-group, which received 40 mg parecoxib before skin incision and at 12 and 24 hours after the first dose; post-group, which received the same dose at wound closure and at 12 and 24 hours after the first dose; and control group, which did not receive any parecoxib. Efficacy and safety of parecoxib were measured based on pain score, morphine consumption, and side effects from both morphine and parecoxib at 24 hours after surgery. Results Initial postoperative pain score, postoperative pain score at rest, and accumulative morphine consumption at 24 hours after surgery were similar between the pre- and post-groups. Despite the significantly lower pain score and morphine consumption in both pre- and post-groups compared with the control group, cumulative morphine consumption at 24 hours after surgery was reduced by approximately 50% in the pre-group and 46% in the post-group compared. Analgesic-related complication incidence was similar in all groups. Conclusions The timing of parecoxib administration, either before or after major spinal surgery, did not affect the safety and analgesic efficacy of pain management. |
| first_indexed | 2024-12-11T18:26:52Z |
| format | Article |
| id | doaj.art-933ed52b3acd4f2188967fbeeb90bee3 |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-12-11T18:26:52Z |
| publishDate | 2018-10-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-933ed52b3acd4f2188967fbeeb90bee32022-12-22T00:55:02ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462018-10-0112589390110.31616/asj.2018.12.5.893946Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine SurgeryRayakorn Moonla0Adisorn Threetipayarak1Chininthon Panpaisarn2Nida Pattayaruk3Unchana Kaewkam4Nipawan Jumpalee5Jatupong Panwilai6 Department of Anesthesiology, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Pharmacy, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Anesthesiology, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Nurse Anesthesia, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Nurse Anesthesia, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Nurse Anesthesia, Chiangmai Neurological Hospital, Chiangmai, Thailand Department of Nurse Anesthesia, Chiangmai Neurological Hospital, Chiangmai, ThailandStudy Design Prospective randomized, double-blind controlled trial. Purpose Here, we aim to compare the efficacy and safety of pain control between pre- and postoperative parecoxib administration in patients who have undergone major spine surgery. Overview of Literature Several studies have compared the efficacy of pre- and postoperative administration of parecoxib, which led to inconclusive results owing to variation in operative time. Preincisional parecoxib administration reduces inflammatory response in major spine surgery requiring longer operative time; however, it may not reduce pain as much as parecoxib administration immediately after surgery would. Methods Totally, 127 patients who underwent major spine surgery were randomly divided into three groups: pre-group, which received 40 mg parecoxib before skin incision and at 12 and 24 hours after the first dose; post-group, which received the same dose at wound closure and at 12 and 24 hours after the first dose; and control group, which did not receive any parecoxib. Efficacy and safety of parecoxib were measured based on pain score, morphine consumption, and side effects from both morphine and parecoxib at 24 hours after surgery. Results Initial postoperative pain score, postoperative pain score at rest, and accumulative morphine consumption at 24 hours after surgery were similar between the pre- and post-groups. Despite the significantly lower pain score and morphine consumption in both pre- and post-groups compared with the control group, cumulative morphine consumption at 24 hours after surgery was reduced by approximately 50% in the pre-group and 46% in the post-group compared. Analgesic-related complication incidence was similar in all groups. Conclusions The timing of parecoxib administration, either before or after major spinal surgery, did not affect the safety and analgesic efficacy of pain management.http://www.asianspinejournal.org/upload/pdf/asj-2018-12-5-893.pdfSpineOrthopedicsPostoperative painPain managementNon-steroidal anti-inflammatory agents |
| spellingShingle | Rayakorn Moonla Adisorn Threetipayarak Chininthon Panpaisarn Nida Pattayaruk Unchana Kaewkam Nipawan Jumpalee Jatupong Panwilai Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery Asian Spine Journal Spine Orthopedics Postoperative pain Pain management Non-steroidal anti-inflammatory agents |
| title | Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery |
| title_full | Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery |
| title_fullStr | Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery |
| title_full_unstemmed | Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery |
| title_short | Comparison of Preoperative and Postoperative Parecoxib Administration for Pain Control Following Major Spine Surgery |
| title_sort | comparison of preoperative and postoperative parecoxib administration for pain control following major spine surgery |
| topic | Spine Orthopedics Postoperative pain Pain management Non-steroidal anti-inflammatory agents |
| url | http://www.asianspinejournal.org/upload/pdf/asj-2018-12-5-893.pdf |
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