Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver
Decheng Meng,1 Fengxia Zhang,2 Wenfei Yu,1 Xin Zhang,1 Guoliang Yin,1 Pengpeng Liang,3 Yanan Feng,1 Suwen Chen,1 Hongshuai Liu1 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 2Department of Neurology, Affiliated Ho...
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| Format: | Article |
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Dove Medical Press
2023-12-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| Online Access: | https://www.dovepress.com/biological-role-and-related-natural-products-of-sirt1-in-nonalcoholic--peer-reviewed-fulltext-article-DMSO |
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| author | Meng D Zhang F Yu W Zhang X Yin G Liang P Feng Y Chen S Liu H |
| author_facet | Meng D Zhang F Yu W Zhang X Yin G Liang P Feng Y Chen S Liu H |
| author_sort | Meng D |
| collection | DOAJ |
| description | Decheng Meng,1 Fengxia Zhang,2 Wenfei Yu,1 Xin Zhang,1 Guoliang Yin,1 Pengpeng Liang,3 Yanan Feng,1 Suwen Chen,1 Hongshuai Liu1 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 2Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 3Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine, Shenzhen, 518001, People’s Republic of ChinaCorrespondence: Fengxia Zhang, Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China, Tel +86-131-5317-5246, Email fxzhang0987@163.comAbstract: Non-alcoholic fatty liver disease(NAFLD) is an umbrella term for a range of diseases ranging from hepatic fat accumulation and steatosis to non-alcoholic steatohepatitis (NASH) in the absence of excessive alcohol consumption and other definite liver damage factors. The incidence of NAFLD has increased significantly in recent years and will continue to grow in the coming decades. NAFLD has become a huge health problem and economic burden. SIRT1 is a member of Sirtuins, a group of highly conserved histone deacetylases regulated by NAD+, and plays a vital role in regulating cholesterol and lipid metabolism, improving oxidative stress, inflammation, and insulin resistance through deacetylating some downstream transcription factors and thus improving NAFLD. Although there are no currently approved drugs for treating NAFLD and some unresolved limitations in developing SIRT1 activators, SIRT1 holds promise as a proper therapeutic target for NAFLD and other metabolic diseases. In recent years, natural products have played an increasingly important role in drug development due to their safety and efficacy. It has been discovered that some natural products may be able to prevent and treat NAFLD by targeting SIRT1 and its related pathways. This paper reviews the mechanism of SIRT1 in the improvement of NALFD and the natural products that regulate NAFLD through SIRT1 and its associated pathways, and discusses the potential of SIRT1 as a therapeutic target for treating NAFLD and the effectiveness of these related natural products as clinical drugs or dietary supplements. These works may provide some new ideas and directions for finding new therapeutic targets for NAFLD and the development of anti-NAFLD drugs with good pharmacodynamic properties. Keywords: NAFLD, SIRT1, natural products, FFA, TG |
| first_indexed | 2024-03-09T02:05:50Z |
| format | Article |
| id | doaj.art-934099ce76e04c258c67a62816c1e337 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-09T02:05:50Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-934099ce76e04c258c67a62816c1e3372023-12-07T18:03:42ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-12-01Volume 164043406488864Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty LiverMeng DZhang FYu WZhang XYin GLiang PFeng YChen SLiu HDecheng Meng,1 Fengxia Zhang,2 Wenfei Yu,1 Xin Zhang,1 Guoliang Yin,1 Pengpeng Liang,3 Yanan Feng,1 Suwen Chen,1 Hongshuai Liu1 1The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 2Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China; 3Shenzhen Hospital, Shanghai University of Traditional Chinese Medicine, Shenzhen, 518001, People’s Republic of ChinaCorrespondence: Fengxia Zhang, Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, People’s Republic of China, Tel +86-131-5317-5246, Email fxzhang0987@163.comAbstract: Non-alcoholic fatty liver disease(NAFLD) is an umbrella term for a range of diseases ranging from hepatic fat accumulation and steatosis to non-alcoholic steatohepatitis (NASH) in the absence of excessive alcohol consumption and other definite liver damage factors. The incidence of NAFLD has increased significantly in recent years and will continue to grow in the coming decades. NAFLD has become a huge health problem and economic burden. SIRT1 is a member of Sirtuins, a group of highly conserved histone deacetylases regulated by NAD+, and plays a vital role in regulating cholesterol and lipid metabolism, improving oxidative stress, inflammation, and insulin resistance through deacetylating some downstream transcription factors and thus improving NAFLD. Although there are no currently approved drugs for treating NAFLD and some unresolved limitations in developing SIRT1 activators, SIRT1 holds promise as a proper therapeutic target for NAFLD and other metabolic diseases. In recent years, natural products have played an increasingly important role in drug development due to their safety and efficacy. It has been discovered that some natural products may be able to prevent and treat NAFLD by targeting SIRT1 and its related pathways. This paper reviews the mechanism of SIRT1 in the improvement of NALFD and the natural products that regulate NAFLD through SIRT1 and its associated pathways, and discusses the potential of SIRT1 as a therapeutic target for treating NAFLD and the effectiveness of these related natural products as clinical drugs or dietary supplements. These works may provide some new ideas and directions for finding new therapeutic targets for NAFLD and the development of anti-NAFLD drugs with good pharmacodynamic properties. Keywords: NAFLD, SIRT1, natural products, FFA, TGhttps://www.dovepress.com/biological-role-and-related-natural-products-of-sirt1-in-nonalcoholic--peer-reviewed-fulltext-article-DMSOnafldsirt1natural productsffatg |
| spellingShingle | Meng D Zhang F Yu W Zhang X Yin G Liang P Feng Y Chen S Liu H Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver Diabetes, Metabolic Syndrome and Obesity nafld sirt1 natural products ffa tg |
| title | Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver |
| title_full | Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver |
| title_fullStr | Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver |
| title_full_unstemmed | Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver |
| title_short | Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver |
| title_sort | biological role and related natural products of sirt1 in nonalcoholic fatty liver |
| topic | nafld sirt1 natural products ffa tg |
| url | https://www.dovepress.com/biological-role-and-related-natural-products-of-sirt1-in-nonalcoholic--peer-reviewed-fulltext-article-DMSO |
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