In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups
In vitro mineralisation in simulated body fluid (SBF) of synthetic polymers continues to be an important area of research as the outcomes cannot be predicted. This study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers, specifically using acrylic acid and itaconic...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2017-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X16300810 |
| _version_ | 1827280836757553152 |
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| author | Norsyahidah Mohd Hidzir David J.T. Hill Darren Martin Lisbeth Grøndahl |
| author_facet | Norsyahidah Mohd Hidzir David J.T. Hill Darren Martin Lisbeth Grøndahl |
| author_sort | Norsyahidah Mohd Hidzir |
| collection | DOAJ |
| description | In vitro mineralisation in simulated body fluid (SBF) of synthetic polymers continues to be an important area of research as the outcomes cannot be predicted. This study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers, specifically using acrylic acid and itaconic acid for grafting. The samples differ with regards to graft density, carboxylate density and polymer topology. The type and amount of mineral produced in 1.5 × SBF was dependent on the sample characteristics as evident from XPS, SEM/EDX, and FTIR spectroscopy. It was found that the graft density affects the mineral phases that form and that low graft density appear to cause co-precipitation of calcium carbonate and calcium phosphate. Linear and branched graft copolymer topology led to hydroxyapatite mineralisation whereas crosslinked graft copolymers resulted in formation of a mixture of calcium-phosphate phases. This study demonstrates that in vitro mineralisation outcomes for carboxylate-containing graft copolymers are complex. The findings of this study have implications for the design of bioactive coatings and are important for understanding the bone-biomaterial interface. |
| first_indexed | 2024-04-24T08:47:45Z |
| format | Article |
| id | doaj.art-9340c8b1c0e448dea6a2d9766e0555f0 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:47:45Z |
| publishDate | 2017-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-9340c8b1c0e448dea6a2d9766e0555f02024-04-16T12:59:28ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2017-03-0121273410.1016/j.bioactmat.2017.02.002In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groupsNorsyahidah Mohd Hidzir0David J.T. Hill1Darren Martin2Lisbeth Grøndahl3School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, AustraliaSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, AustraliaAustralian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, QLD, 4072, AustraliaSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD, 4072, AustraliaIn vitro mineralisation in simulated body fluid (SBF) of synthetic polymers continues to be an important area of research as the outcomes cannot be predicted. This study evaluates a series of ePTFE membranes grafted with carboxylate-containing copolymers, specifically using acrylic acid and itaconic acid for grafting. The samples differ with regards to graft density, carboxylate density and polymer topology. The type and amount of mineral produced in 1.5 × SBF was dependent on the sample characteristics as evident from XPS, SEM/EDX, and FTIR spectroscopy. It was found that the graft density affects the mineral phases that form and that low graft density appear to cause co-precipitation of calcium carbonate and calcium phosphate. Linear and branched graft copolymer topology led to hydroxyapatite mineralisation whereas crosslinked graft copolymers resulted in formation of a mixture of calcium-phosphate phases. This study demonstrates that in vitro mineralisation outcomes for carboxylate-containing graft copolymers are complex. The findings of this study have implications for the design of bioactive coatings and are important for understanding the bone-biomaterial interface.http://www.sciencedirect.com/science/article/pii/S2452199X16300810Simulated body fluidExpanded poly(tetrafluoroethylene)Graft copolymerisationCarboxylate groups |
| spellingShingle | Norsyahidah Mohd Hidzir David J.T. Hill Darren Martin Lisbeth Grøndahl In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups Bioactive Materials Simulated body fluid Expanded poly(tetrafluoroethylene) Graft copolymerisation Carboxylate groups |
| title | In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups |
| title_full | In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups |
| title_fullStr | In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups |
| title_full_unstemmed | In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups |
| title_short | In vitro mineralisation of grafted ePTFE membranes carrying carboxylate groups |
| title_sort | in vitro mineralisation of grafted eptfe membranes carrying carboxylate groups |
| topic | Simulated body fluid Expanded poly(tetrafluoroethylene) Graft copolymerisation Carboxylate groups |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X16300810 |
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