Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo
Irisin, a skeletal-muscle secreted myokine, facilitates muscle-bone crosstalk and skeletal remodeling in part by its action on osteoblasts and osteocytes. In this study, we investigated whether irisin directly regulates osteoclasts. In vitro, irisin (2–10 ng/mL) increased osteoclast differentiation...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/58172 |