Neuregulin-1 regulates cell adhesion via an ErbB2/phosphoinositide-3 kinase/Akt-dependent pathway: potential implications for schizophrenia and cancer.
Neuregulin-1 (NRG1) is a putative schizophrenia susceptibility gene involved extensively in central nervous system development as well as cancer invasion and metastasis. Using a B lymphoblast cell model, we previously demonstrated impairment in NRG1alpha-mediated migration in cells derived from pati...
Main Authors: | Christopher G Kanakry, Zhen Li, Yoko Nakai, Yoshitatsu Sei, Daniel R Weinberger |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-12-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2147048?pdf=render |
Similar Items
-
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
by: Yoshitatsu Sei, et al.
Published: (2010-05-01) -
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
by: Law, A, et al.
Published: (2012) -
Alterations of neuregulin1 and ErbB4 expression in the cerebellum in schizophrenia
by: Law, A, et al.
Published: (2005) -
Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
by: Sei, Y, et al.
Published: (2010) -
Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia
by: McGinnis Ralph, et al.
Published: (2007-06-01)