Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis.
Ran (ras-related nuclear protein) is a small GTPase belonging to the RAS superfamily that is specialized in nuclear trafficking. Through different accessory proteins, Ran plays key roles in several processes including nuclear import-export, mitotic progression and spindle assembly. Consequently, Ran...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6177115?pdf=render |
| _version_ | 1818821851752693760 |
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| author | Ugo Coppola Filomena Caccavale Marta Scelzo Nicholas D Holland Filomena Ristoratore Salvatore D'Aniello |
| author_facet | Ugo Coppola Filomena Caccavale Marta Scelzo Nicholas D Holland Filomena Ristoratore Salvatore D'Aniello |
| author_sort | Ugo Coppola |
| collection | DOAJ |
| description | Ran (ras-related nuclear protein) is a small GTPase belonging to the RAS superfamily that is specialized in nuclear trafficking. Through different accessory proteins, Ran plays key roles in several processes including nuclear import-export, mitotic progression and spindle assembly. Consequently, Ran dysfunction has been linked to several human pathologies. This work illustrates the high degree of amino acid conservation of Ran orthologues across evolution, reflected in its conserved role in nuclear trafficking. Moreover, we studied the evolutionary scenario of the pre-metazoan genetic linkage between Ran and Stx, and we hypothesized that chromosomal proximity of these two genes across metazoans could be related to a regulatory logic or a functional linkage. We studied, for the first time, Ran expression during amphioxus development and reported its presence in the neural vesicle, mouth, gill slits and gut corresponding to body regions involved in active cell division. |
| first_indexed | 2024-12-18T23:14:46Z |
| format | Article |
| id | doaj.art-93468e9fb51449a9ba09d4fefea2ecf9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-18T23:14:46Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-93468e9fb51449a9ba09d4fefea2ecf92022-12-21T20:48:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011310e019693010.1371/journal.pone.0196930Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis.Ugo CoppolaFilomena CaccavaleMarta ScelzoNicholas D HollandFilomena RistoratoreSalvatore D'AnielloRan (ras-related nuclear protein) is a small GTPase belonging to the RAS superfamily that is specialized in nuclear trafficking. Through different accessory proteins, Ran plays key roles in several processes including nuclear import-export, mitotic progression and spindle assembly. Consequently, Ran dysfunction has been linked to several human pathologies. This work illustrates the high degree of amino acid conservation of Ran orthologues across evolution, reflected in its conserved role in nuclear trafficking. Moreover, we studied the evolutionary scenario of the pre-metazoan genetic linkage between Ran and Stx, and we hypothesized that chromosomal proximity of these two genes across metazoans could be related to a regulatory logic or a functional linkage. We studied, for the first time, Ran expression during amphioxus development and reported its presence in the neural vesicle, mouth, gill slits and gut corresponding to body regions involved in active cell division.http://europepmc.org/articles/PMC6177115?pdf=render |
| spellingShingle | Ugo Coppola Filomena Caccavale Marta Scelzo Nicholas D Holland Filomena Ristoratore Salvatore D'Aniello Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. PLoS ONE |
| title | Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. |
| title_full | Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. |
| title_fullStr | Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. |
| title_full_unstemmed | Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. |
| title_short | Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis. |
| title_sort | ran gtpase an eukaryotic gene novelty is involved in amphioxus mitosis |
| url | http://europepmc.org/articles/PMC6177115?pdf=render |
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