Intraocular Adeno-Associated Virus-Mediated Transgene Endothelin-1 Delivery to the Rat Eye Induces Functional Changes Indicative of Retinal Ischemia—A Potential Chronic Glaucoma Model

Intraocular Adeno-Associated Virus-Mediated Transgene Endothelin-1 Delivery to the Rat Eye Induces Functional Changes Indicative of Retinal Ischemia—A Potential Chronic Glaucoma Model

Endothelin-1 (ET-1) overactivity has been implicated as a factor contributing to glaucomatous neuropathy, and it has been utilized in animal models of retinal ischemia. The functional effects of long-term ET-1 exposure and possible compensatory mechanisms have, however, not been investigated. This w...

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Bibliographic Details
Main Authors: Karin M. L. Nordahl, Vadim Fedulov, Anja Holm, Kristian A. Haanes
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
AAV vector
animal model
compensatory response
electroretinography
endothelin-1
gene expression
Online Access:https://www.mdpi.com/2073-4409/12/15/1987

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