Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation

Abstract A recently developed synthetic retinoid abrogates proliferation and induces apoptosis of drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms of how the synthetic retinoid induces cancer‐stem‐cell‐like cell tumor‐repopulating cell (TRC) apoptosis are elus...

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Bibliographic Details
Main Authors: Yao Zhang, Qi Dong, Quanlin An, Chumei Zhang, Erfan Mohagheghian, Bing Niu, Feng Qi, Fuxiang Wei, Sihan Chen, Xinman Chen, Anqi Wang, Xin Cao, Ning Wang, Junwei Chen
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Advanced Science
Subjects:
cancer stem cells
cell apoptosis
chromatin decondensation
drug efficacy
tension force
Online Access:https://doi.org/10.1002/advs.202203173

Internet

https://doi.org/10.1002/advs.202203173

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