<i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation
Obesity has become a worldwide health problem, and many significant inflammatory markers have been associated with the risk of side effects of obesity and obesity-related diseases. After a normal diet or high-fat diet with high-fructose water (HFHF) for 8 weeks, male Wistar rats were divided randoml...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/9/4444 |
| _version_ | 1797536529065705472 |
|---|---|
| author | Miey Park Eun-Jung Park So-Hyeun Kim Hae-Jeung Lee |
| author_facet | Miey Park Eun-Jung Park So-Hyeun Kim Hae-Jeung Lee |
| author_sort | Miey Park |
| collection | DOAJ |
| description | Obesity has become a worldwide health problem, and many significant inflammatory markers have been associated with the risk of side effects of obesity and obesity-related diseases. After a normal diet or high-fat diet with high-fructose water (HFHF) for 8 weeks, male Wistar rats were divided randomly into four experimental groups according to body weight. Next, for 8 weeks, a normal diet, HFHF diet, and HFHF diet with <i>L. plantarum</i> strains ATG-K2 or ATG-K6 were administered orally. Compared to the control group, the HFHF diet group showed significantly increased visceral fat, epididymal fat, and liver weight. The mRNA and protein expression levels of FAS and SREBP-1c were higher in the HFHF diet group than in the HFHF diet with <i>L. plantarum</i> strains ATG-K2 and ATG-K6. The HFHF diet with <i>L. plantarum</i> strain ATG-K2 showed significantly decreased inflammatory cytokine expression in the serum and small intestine compared to the HFHF diet group. Furthermore, histological morphology showed minor cell injury, less severe infiltration, and longer villi height in the small intestine ileum of the HFHF diet with <i>L. plantarum</i> strains groups than in the HFHF diet group. These results suggest that <i>L. plantarum</i> strains K2 and K6 may help reduce intestinal inflammation and could be used as treatment alternatives for intestinal inflammatory reactions and obesity. |
| first_indexed | 2024-03-10T12:01:03Z |
| format | Article |
| id | doaj.art-934797290c72438eb435de76f67c5f5e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:01:03Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-934797290c72438eb435de76f67c5f5e2023-11-21T16:56:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01229444410.3390/ijms22094444<i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal InflammationMiey Park0Eun-Jung Park1So-Hyeun Kim2Hae-Jeung Lee3Institute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, KoreaInstitute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, KoreaInstitute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, KoreaInstitute for Aging and Clinical Nutrition Research, Gachon University, Seongnam-si 13120, KoreaObesity has become a worldwide health problem, and many significant inflammatory markers have been associated with the risk of side effects of obesity and obesity-related diseases. After a normal diet or high-fat diet with high-fructose water (HFHF) for 8 weeks, male Wistar rats were divided randomly into four experimental groups according to body weight. Next, for 8 weeks, a normal diet, HFHF diet, and HFHF diet with <i>L. plantarum</i> strains ATG-K2 or ATG-K6 were administered orally. Compared to the control group, the HFHF diet group showed significantly increased visceral fat, epididymal fat, and liver weight. The mRNA and protein expression levels of FAS and SREBP-1c were higher in the HFHF diet group than in the HFHF diet with <i>L. plantarum</i> strains ATG-K2 and ATG-K6. The HFHF diet with <i>L. plantarum</i> strain ATG-K2 showed significantly decreased inflammatory cytokine expression in the serum and small intestine compared to the HFHF diet group. Furthermore, histological morphology showed minor cell injury, less severe infiltration, and longer villi height in the small intestine ileum of the HFHF diet with <i>L. plantarum</i> strains groups than in the HFHF diet group. These results suggest that <i>L. plantarum</i> strains K2 and K6 may help reduce intestinal inflammation and could be used as treatment alternatives for intestinal inflammatory reactions and obesity.https://www.mdpi.com/1422-0067/22/9/4444obesitysmall intestineinflammation<i>Lactobacillus</i> spp. |
| spellingShingle | Miey Park Eun-Jung Park So-Hyeun Kim Hae-Jeung Lee <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation International Journal of Molecular Sciences obesity small intestine inflammation <i>Lactobacillus</i> spp. |
| title | <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation |
| title_full | <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation |
| title_fullStr | <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation |
| title_full_unstemmed | <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation |
| title_short | <i>Lactobacillus plantarum</i> ATG-K2 and ATG-K6 Ameliorates High-Fat with High-Fructose Induced Intestinal Inflammation |
| title_sort | i lactobacillus plantarum i atg k2 and atg k6 ameliorates high fat with high fructose induced intestinal inflammation |
| topic | obesity small intestine inflammation <i>Lactobacillus</i> spp. |
| url | https://www.mdpi.com/1422-0067/22/9/4444 |
| work_keys_str_mv | AT mieypark ilactobacillusplantarumiatgk2andatgk6ameliorateshighfatwithhighfructoseinducedintestinalinflammation AT eunjungpark ilactobacillusplantarumiatgk2andatgk6ameliorateshighfatwithhighfructoseinducedintestinalinflammation AT sohyeunkim ilactobacillusplantarumiatgk2andatgk6ameliorateshighfatwithhighfructoseinducedintestinalinflammation AT haejeunglee ilactobacillusplantarumiatgk2andatgk6ameliorateshighfatwithhighfructoseinducedintestinalinflammation |