Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States
Background and Aims: This study compared disease burden, experiences, and health-related quality of life (HRQoL) between patients with Crohn’s perianal fistulas (CPFs) and those with Crohn’s disease (CD) without perianal fistulas (PFs; non-PF CD). Methods: This cross-sectional, observational study w...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572323001310 |
| _version_ | 1797448002988670976 |
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| author | Jeanne Jiang Susan E. Cazzetta Amod Athavale Maja Kuharic Tao Fan Abigail Silber Vijay Abilash Nandini Hadker Emily Sharpe Pradeep P. Nazarey |
| author_facet | Jeanne Jiang Susan E. Cazzetta Amod Athavale Maja Kuharic Tao Fan Abigail Silber Vijay Abilash Nandini Hadker Emily Sharpe Pradeep P. Nazarey |
| author_sort | Jeanne Jiang |
| collection | DOAJ |
| description | Background and Aims: This study compared disease burden, experiences, and health-related quality of life (HRQoL) between patients with Crohn’s perianal fistulas (CPFs) and those with Crohn’s disease (CD) without perianal fistulas (PFs; non-PF CD). Methods: This cross-sectional, observational study was conducted in 3 cohorts of US patients aged 18–89 years with self-reported, physician-diagnosed CD: (1) non-PF CD; (2) CPF without PF-related surgery; and (3) CPF with PF-related surgery. Data on medical and surgical interventions, CD-specific symptoms, HRQoL (assessed using the Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaires), and fecal incontinence (assessed using Revised Faecal Incontinence Scale and Fecal Incontinence Quality of Life questionnaires) were collected via a web-enabled questionnaire. Results: In total, 403 patients with CD completed the questionnaire (non-PF CD, n = 300; CPF without surgery, n = 51; CPF with surgery, n = 52). A high symptom burden was seen across cohorts. More patients with CPF underwent ≥1 CD-related surgery and experienced ≥1 failure of CD-related surgery (79% and 20%) vs non-PF CD (53% and 9%; P < .001). Overall HRQoL outcomes were worse for patients with CPF vs non-PF CD, with significantly worse Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaire scores for those without PF-related surgery (P < .01). Across all cohorts, 58% of patients reported experiencing fecal incontinence, which had a greater negative impact (higher Revised Faecal Incontinence Scale scores; lower Fecal Incontinence Quality of Life scores) in patients with CPF vs non-PF CD. Conclusion: Patients with CPF experience substantial HRQoL burden, reflecting the impact of symptoms and medical/surgical interventions. These results may help to inform comprehensive care strategies to improve patient HRQoL. |
| first_indexed | 2024-03-09T14:04:06Z |
| format | Article |
| id | doaj.art-93487da4b70b464e9e38e53d79c03b96 |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-03-09T14:04:06Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-93487da4b70b464e9e38e53d79c03b962023-11-30T05:12:10ZengElsevierGastro Hep Advances2772-57232023-01-012810661076Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United StatesJeanne Jiang0Susan E. Cazzetta1Amod Athavale2Maja Kuharic3Tao Fan4Abigail Silber5Vijay Abilash6Nandini Hadker7Emily Sharpe8Pradeep P. Nazarey9Takeda Pharmaceuticals USA, Inc., Lexington, Massachusetts; Correspondence: Address correspondence to: Jeanne Jiang, Takeda Pharmaceuticals USA, Inc., 95 Hayden Ave, Lexington, Massachusetts 02421.Takeda Pharmaceuticals USA, Inc., Lexington, MassachusettsTrinity Life Sciences, Waltham, MassachusettsDepartment of Pharmacy Systems, Outcomes and Policy, College of Pharmacy, University of Illinois, Chicago, IllinoisTakeda Pharmaceuticals USA, Inc., Lexington, MassachusettsTrinity Life Sciences, Waltham, MassachusettsTrinity Life Sciences, Waltham, MassachusettsTrinity Life Sciences, Waltham, MassachusettsTrinity Life Sciences, Waltham, MassachusettsTakeda Pharmaceuticals USA, Inc., Lexington, MassachusettsBackground and Aims: This study compared disease burden, experiences, and health-related quality of life (HRQoL) between patients with Crohn’s perianal fistulas (CPFs) and those with Crohn’s disease (CD) without perianal fistulas (PFs; non-PF CD). Methods: This cross-sectional, observational study was conducted in 3 cohorts of US patients aged 18–89 years with self-reported, physician-diagnosed CD: (1) non-PF CD; (2) CPF without PF-related surgery; and (3) CPF with PF-related surgery. Data on medical and surgical interventions, CD-specific symptoms, HRQoL (assessed using the Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaires), and fecal incontinence (assessed using Revised Faecal Incontinence Scale and Fecal Incontinence Quality of Life questionnaires) were collected via a web-enabled questionnaire. Results: In total, 403 patients with CD completed the questionnaire (non-PF CD, n = 300; CPF without surgery, n = 51; CPF with surgery, n = 52). A high symptom burden was seen across cohorts. More patients with CPF underwent ≥1 CD-related surgery and experienced ≥1 failure of CD-related surgery (79% and 20%) vs non-PF CD (53% and 9%; P < .001). Overall HRQoL outcomes were worse for patients with CPF vs non-PF CD, with significantly worse Short Inflammatory Bowel Disease and 5-dimension EuroQol questionnaire scores for those without PF-related surgery (P < .01). Across all cohorts, 58% of patients reported experiencing fecal incontinence, which had a greater negative impact (higher Revised Faecal Incontinence Scale scores; lower Fecal Incontinence Quality of Life scores) in patients with CPF vs non-PF CD. Conclusion: Patients with CPF experience substantial HRQoL burden, reflecting the impact of symptoms and medical/surgical interventions. These results may help to inform comprehensive care strategies to improve patient HRQoL.http://www.sciencedirect.com/science/article/pii/S2772572323001310Crohn’s Perianal FistulasFecal IncontinenceHealth-Related Quality of LifeSymptom Burden |
| spellingShingle | Jeanne Jiang Susan E. Cazzetta Amod Athavale Maja Kuharic Tao Fan Abigail Silber Vijay Abilash Nandini Hadker Emily Sharpe Pradeep P. Nazarey Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States Gastro Hep Advances Crohn’s Perianal Fistulas Fecal Incontinence Health-Related Quality of Life Symptom Burden |
| title | Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States |
| title_full | Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States |
| title_fullStr | Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States |
| title_full_unstemmed | Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States |
| title_short | Observational Burden of Illness Study in Patients With Crohn’s Disease With and Without Perianal Fistulas in the United States |
| title_sort | observational burden of illness study in patients with crohn s disease with and without perianal fistulas in the united states |
| topic | Crohn’s Perianal Fistulas Fecal Incontinence Health-Related Quality of Life Symptom Burden |
| url | http://www.sciencedirect.com/science/article/pii/S2772572323001310 |
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