The Effect of Iodised Poly-3-Hydroxy Butyrate on DNA and BSA
Objective:An important criterion that radiopaque poly-3-hydroxy butyrate (PHB) derivatives synthesized and characterized by our study group do not interact with DNA and bovine albumin to be developed as an intravenous contrast agent for radiological imaging.Methods:Interactions of radiopaque PHB der...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-04-01
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| Series: | Bezmiâlem Science |
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| Online Access: |
http://bezmialemscience.org/archives/archive-detail/article-preview/the-effect-of-odised-poly-3-hydroxy-butyrate-on-dn/47235
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| Summary: | Objective:An important criterion that radiopaque poly-3-hydroxy butyrate (PHB) derivatives synthesized and characterized by our study group do not interact with DNA and bovine albumin to be developed as an intravenous contrast agent for radiological imaging.Methods:Interactions of radiopaque PHB derivatives between bovine serum albumin (BSA) and deoxyribonucleic acid (pUC19 DNA and polymerase chain reaction product) were investigated using absorption spectroscopy and agarose gel electrophoresis techniques.Results:Absorption spectroscopy results showed that the radiopaque PHB derivatives did not show any interaction with BSA. Doublestranded annular DNA showed that the interaction between the double-stranded forms of linear DNA did not cause any damage.Conclusion:It was determined that it did not interact with both BSA and various DNA forms. |
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| ISSN: | 2148-2373 2148-2373 |