Mitochondrial Oxidative Phosphorylation in Viral Infections
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling, generating precursor molecules, immune response,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/12/2380 |
| _version_ | 1797379101543104512 |
|---|---|
| author | Neeraja Purandare Esha Ghosalkar Lawrence I. Grossman Siddhesh Aras |
| author_facet | Neeraja Purandare Esha Ghosalkar Lawrence I. Grossman Siddhesh Aras |
| author_sort | Neeraja Purandare |
| collection | DOAJ |
| description | Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling, generating precursor molecules, immune response, and apoptosis to name a few. Dysfunctional mitochondria resulting from a departure in homeostasis results in cellular degeneration. Viruses hijack host cell machinery to facilitate their own replication in the absence of a bonafide replication machinery. Replication being an energy intensive process necessitates regulation of the host cell oxidative phosphorylation occurring at the electron transport chain in the mitochondria to generate energy. Mitochondria, therefore, can be an attractive therapeutic target by limiting energy for viral replication. In this review we focus on the physiology of oxidative phosphorylation and on the limited studies highlighting the regulatory effects viruses induce on the electron transport chain. |
| first_indexed | 2024-03-08T20:17:20Z |
| format | Article |
| id | doaj.art-93497b0594af46a9b3190ddcc2b0ea2a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-08T20:17:20Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-93497b0594af46a9b3190ddcc2b0ea2a2023-12-22T14:49:16ZengMDPI AGViruses1999-49152023-12-011512238010.3390/v15122380Mitochondrial Oxidative Phosphorylation in Viral InfectionsNeeraja Purandare0Esha Ghosalkar1Lawrence I. Grossman2Siddhesh Aras3Center for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USACenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USACenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USACenter for Molecular Medicine and Genetics, School of Medicine, Wayne State University, Detroit, MI 48201, USAMitochondria have been identified as the “powerhouse” of the cell, generating the cellular energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted role of the mitochondrion in processes such as cellular stress signaling, generating precursor molecules, immune response, and apoptosis to name a few. Dysfunctional mitochondria resulting from a departure in homeostasis results in cellular degeneration. Viruses hijack host cell machinery to facilitate their own replication in the absence of a bonafide replication machinery. Replication being an energy intensive process necessitates regulation of the host cell oxidative phosphorylation occurring at the electron transport chain in the mitochondria to generate energy. Mitochondria, therefore, can be an attractive therapeutic target by limiting energy for viral replication. In this review we focus on the physiology of oxidative phosphorylation and on the limited studies highlighting the regulatory effects viruses induce on the electron transport chain.https://www.mdpi.com/1999-4915/15/12/2380oxidative phosphorylationreactive oxygen speciesNADH dehydrogenasesuccinate dehydrogensasecytochrome bc1 complexcytochrome <i>c</i> oxidase |
| spellingShingle | Neeraja Purandare Esha Ghosalkar Lawrence I. Grossman Siddhesh Aras Mitochondrial Oxidative Phosphorylation in Viral Infections Viruses oxidative phosphorylation reactive oxygen species NADH dehydrogenase succinate dehydrogensase cytochrome bc1 complex cytochrome <i>c</i> oxidase |
| title | Mitochondrial Oxidative Phosphorylation in Viral Infections |
| title_full | Mitochondrial Oxidative Phosphorylation in Viral Infections |
| title_fullStr | Mitochondrial Oxidative Phosphorylation in Viral Infections |
| title_full_unstemmed | Mitochondrial Oxidative Phosphorylation in Viral Infections |
| title_short | Mitochondrial Oxidative Phosphorylation in Viral Infections |
| title_sort | mitochondrial oxidative phosphorylation in viral infections |
| topic | oxidative phosphorylation reactive oxygen species NADH dehydrogenase succinate dehydrogensase cytochrome bc1 complex cytochrome <i>c</i> oxidase |
| url | https://www.mdpi.com/1999-4915/15/12/2380 |
| work_keys_str_mv | AT neerajapurandare mitochondrialoxidativephosphorylationinviralinfections AT eshaghosalkar mitochondrialoxidativephosphorylationinviralinfections AT lawrenceigrossman mitochondrialoxidativephosphorylationinviralinfections AT siddhesharas mitochondrialoxidativephosphorylationinviralinfections |