Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

Diabetic nephropathy (DN) is a severe complication of diabetes, characterized by changes in kidney structure and function. The natural product rosmarinic acid (RA) has demonstrated therapeutic effects, including anti-inflammation and anti-oxidative-stress, in renal damage or dysfunction. In this stu...

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Bibliographic Details
Main Authors: Junhui Chen, Qian Zhang, Jinan Guo, Di Gu, Jing Liu, Piao Luo, Yunmeng Bai, Jiayun Chen, Xinzhou Zhang, Sheng Nie, Chunbo Chen, Yulin Feng, Jigang Wang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Rosmarinic acid
Diabetic nephropathy
scRNA sequencing
Injury
Oxidative stress
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524000054

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