Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats
The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. Th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
1998-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/41/4/0167/ |
| _version_ | 1811334513638244352 |
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| author | Vladimír Bláha Zhong-jin Yang Michael Meguid Jia-ke Chai Zdeněk Zadák |
| author_facet | Vladimír Bláha Zhong-jin Yang Michael Meguid Jia-ke Chai Zdeněk Zadák |
| author_sort | Vladimír Bláha |
| collection | DOAJ |
| description | The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. The present study investigated the effect of systemic nicotine administration on the rat feeding pattern. Because of gender differences in the effects of nicotine, both male and female rats were studied. Alzet mini-osmotic pumps (Model 2001) and the automated rat eatometer were used to evaluate the feeding pattern of male and female Fischer 344 rats during seven days of systemic nicotine infusion (6 mg/kg b.w. s.c.). The main findings are: 1) systemic nicotine infusion decreased food intake in both sexes; 2) the decreased food intake was due to significantly reduced meal sizes while meal numbers were not altered significantly in either males or females; 3) the cyclical pattern of vaginal smears, food intake, meal number and meal size of female rats was not affected by nicotine administration. We conclude that the feeding suppressive effect of nicotine, which is due to reduced meal sizes and thus satiation, is not sex-hormones related. |
| first_indexed | 2024-04-13T17:09:08Z |
| format | Article |
| id | doaj.art-934a3e8b8cbb4864b92afc14becbc95a |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-13T17:09:08Z |
| publishDate | 1998-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-934a3e8b8cbb4864b92afc14becbc95a2022-12-22T02:38:20ZengKarolinum PressActa Medica1211-42861805-96941998-01-0141416717310.14712/18059694.2019.184Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female RatsVladimír Bláha0Zhong-jin Yang1Michael Meguid2Jia-ke Chai3Zdeněk Zadák4Department of Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech RepublicNeuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse, NY 13210, USANeuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse, NY 13210, USANeuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse, NY 13210, USADepartment of Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech RepublicThe appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. The present study investigated the effect of systemic nicotine administration on the rat feeding pattern. Because of gender differences in the effects of nicotine, both male and female rats were studied. Alzet mini-osmotic pumps (Model 2001) and the automated rat eatometer were used to evaluate the feeding pattern of male and female Fischer 344 rats during seven days of systemic nicotine infusion (6 mg/kg b.w. s.c.). The main findings are: 1) systemic nicotine infusion decreased food intake in both sexes; 2) the decreased food intake was due to significantly reduced meal sizes while meal numbers were not altered significantly in either males or females; 3) the cyclical pattern of vaginal smears, food intake, meal number and meal size of female rats was not affected by nicotine administration. We conclude that the feeding suppressive effect of nicotine, which is due to reduced meal sizes and thus satiation, is not sex-hormones related.https://actamedica.lfhk.cuni.cz/41/4/0167/NicotineRatsMale and femaleFeeding patternMeal sizeMeal number |
| spellingShingle | Vladimír Bláha Zhong-jin Yang Michael Meguid Jia-ke Chai Zdeněk Zadák Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats Acta Medica Nicotine Rats Male and female Feeding pattern Meal size Meal number |
| title | Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats |
| title_full | Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats |
| title_fullStr | Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats |
| title_full_unstemmed | Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats |
| title_short | Systemic Nicotine Administration Suppresses Food Intake Via Reduced Meal Sizes in Both Male and Female Rats |
| title_sort | systemic nicotine administration suppresses food intake via reduced meal sizes in both male and female rats |
| topic | Nicotine Rats Male and female Feeding pattern Meal size Meal number |
| url | https://actamedica.lfhk.cuni.cz/41/4/0167/ |
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