Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis
Background/Aims: To investigate the risk of metabolic syndrome and fatty liver diseases in gastric cancer survivors compared to non-cancer subjects. Methods: The data from the health screening registry of the Gangnam Severance Hospital from 2014–2019 was used. Ninety-one gastric cancer survivors an...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Jin Publishing & Printing Co.
2023-04-01
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| Series: | The Korean Journal of Gastroenterology |
| Subjects: | |
| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=5905&vmd=Full |
| _version_ | 1797265338828587008 |
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| author | Sang Jo Han Su Jung Baik Young Hoon Yoon Jie Hyun Kim Hye Sun Lee Soyoung Jeon Hyojin Park |
| author_facet | Sang Jo Han Su Jung Baik Young Hoon Yoon Jie Hyun Kim Hye Sun Lee Soyoung Jeon Hyojin Park |
| author_sort | Sang Jo Han |
| collection | DOAJ |
| description | Background/Aims: To investigate the risk of metabolic syndrome and fatty liver diseases in gastric cancer survivors compared to non-cancer subjects.
Methods: The data from the health screening registry of the Gangnam Severance Hospital from 2014–2019 was used. Ninety-one gastric cancer survivors and a propensity-score-matching 445 non-cancer subjects were analyzed. Gastric cancer survivors were divided into those with surgical treatment (OpGC, n=66) and non-surgical treatment (non-OpGC, n=25). Metabolic syndrome, fatty liver by ultrasonography, and metabolic dysfunction-associated fatty liver disease (MAFLD) were assessed.
Results: Metabolic syndrome was in 15.4% of gastric cancer survivors (OpGC; 13.6%, non-OpGC; 20.0%). Fatty liver by ultrasonography was in 35.2% in gastric cancer survivors (OpGC; 30.3%, non-OpGC: 48.0%). MAFLD was in 27.5% of gastric cancer survivor (OpGC; 21.2%, non-OpGC; 44.0%). After adjusting for age, sex, smoking, and alcohol, the risk of metabolic syndrome was lower in OpGC than in non-cancer subjects (OR, 0.372; 95% CI, 0.176-0.786, p=0.010). After adjusting, OpGC showed lower risks of fatty liver by ultrasonography (OR, 0.545; 95% CI, 0.306-0.970, p=0.039) and MAFLD (OR, 0.375; 95% CI, 0.197-0.711, p=0.003) than did non-cancer subjects. There were no significant differences in the risks of metabolic syndrome and fatty liver diseases between non-OpGC and non-cancer subjects.
Conclusions: OpGC showed lower risks of metabolic syndrome, fatty liver by ultrasonography, and MAFLD than non-cancer subjects, but there were no significant differences in the risks between non-OpGC and non-cancer subjects. Further studies on metabolic syndrome and fatty liver diseases in gastric cancer survivors are warranted. |
| first_indexed | 2024-04-25T00:43:13Z |
| format | Article |
| id | doaj.art-934bb4d6978741e683b02d8838af9424 |
| institution | Directory Open Access Journal |
| issn | 1598-9992 2233-6869 |
| language | English |
| last_indexed | 2024-04-25T00:43:13Z |
| publishDate | 2023-04-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj.art-934bb4d6978741e683b02d8838af94242024-03-12T08:01:27ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692023-04-0181415416210.4166/kjg.2022.113Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched AnalysisSang Jo Han0Su Jung Baik1Young Hoon Yoon2Jie Hyun Kim3Hye Sun Lee4Soyoung Jeon5Hyojin Park6https://orcid.org/0000-0003-4814-8330Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaHealthcare Research Team, Health Promotion Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaBiostatistics Collaboration Unit, Medical Research Center, Yonsei University College of Medicine, Seoul, KoreaBiostatistics Collaboration Unit, Medical Research Center, Yonsei University College of Medicine, Seoul, KoreaDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaBackground/Aims: To investigate the risk of metabolic syndrome and fatty liver diseases in gastric cancer survivors compared to non-cancer subjects. Methods: The data from the health screening registry of the Gangnam Severance Hospital from 2014–2019 was used. Ninety-one gastric cancer survivors and a propensity-score-matching 445 non-cancer subjects were analyzed. Gastric cancer survivors were divided into those with surgical treatment (OpGC, n=66) and non-surgical treatment (non-OpGC, n=25). Metabolic syndrome, fatty liver by ultrasonography, and metabolic dysfunction-associated fatty liver disease (MAFLD) were assessed. Results: Metabolic syndrome was in 15.4% of gastric cancer survivors (OpGC; 13.6%, non-OpGC; 20.0%). Fatty liver by ultrasonography was in 35.2% in gastric cancer survivors (OpGC; 30.3%, non-OpGC: 48.0%). MAFLD was in 27.5% of gastric cancer survivor (OpGC; 21.2%, non-OpGC; 44.0%). After adjusting for age, sex, smoking, and alcohol, the risk of metabolic syndrome was lower in OpGC than in non-cancer subjects (OR, 0.372; 95% CI, 0.176-0.786, p=0.010). After adjusting, OpGC showed lower risks of fatty liver by ultrasonography (OR, 0.545; 95% CI, 0.306-0.970, p=0.039) and MAFLD (OR, 0.375; 95% CI, 0.197-0.711, p=0.003) than did non-cancer subjects. There were no significant differences in the risks of metabolic syndrome and fatty liver diseases between non-OpGC and non-cancer subjects. Conclusions: OpGC showed lower risks of metabolic syndrome, fatty liver by ultrasonography, and MAFLD than non-cancer subjects, but there were no significant differences in the risks between non-OpGC and non-cancer subjects. Further studies on metabolic syndrome and fatty liver diseases in gastric cancer survivors are warranted.https://www.kjg.or.kr/journal/view.html?uid=5905&vmd=Fullcancer survivorsstomach neoplasmsmetabolic syndromefatty liver |
| spellingShingle | Sang Jo Han Su Jung Baik Young Hoon Yoon Jie Hyun Kim Hye Sun Lee Soyoung Jeon Hyojin Park Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis The Korean Journal of Gastroenterology cancer survivors stomach neoplasms metabolic syndrome fatty liver |
| title | Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis |
| title_full | Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis |
| title_fullStr | Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis |
| title_full_unstemmed | Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis |
| title_short | Risk of Metabolic Syndrome and Fatty Liver Diseases in Gastric Cancer Survivors: A Propensity Score-Matched Analysis |
| title_sort | risk of metabolic syndrome and fatty liver diseases in gastric cancer survivors a propensity score matched analysis |
| topic | cancer survivors stomach neoplasms metabolic syndrome fatty liver |
| url | https://www.kjg.or.kr/journal/view.html?uid=5905&vmd=Full |
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