Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer
BackgroundColorectal cancer (CRC) remains a major global health concern, with significant morbidity and mortality rates. In this study, we aimed to develop a comprehensive blood indicator based on systemic inflammation and nutritional condition to predict the prognosis of resectable CRC patients.Met...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1279487/full |
| _version_ | 1797511724885082112 |
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| author | Hao Cai Jiancheng Li Yu Chen Qiao Zhang Yang Liu Houjun Jia |
| author_facet | Hao Cai Jiancheng Li Yu Chen Qiao Zhang Yang Liu Houjun Jia |
| author_sort | Hao Cai |
| collection | DOAJ |
| description | BackgroundColorectal cancer (CRC) remains a major global health concern, with significant morbidity and mortality rates. In this study, we aimed to develop a comprehensive blood indicator based on systemic inflammation and nutritional condition to predict the prognosis of resectable CRC patients.MethodsA retrospective cohort of 210 CRC patients who underwent radical resection at the First Affiliated Hospital of Chongqing Medical University, China, between January 2015 and December 2017, was included in the analysis. Baseline characteristics, preoperative blood markers, including neutrophil count, monocyte count, lymphocyte count, platelets, albumin, and CEA were retrospectively reviewed. Various blood indicators, such as NLR, PLR, MLR, SIRI and OPNI were calculated. The least absolute shrinkage and selection operator (LASSO) method was employed to select indicators to establish a novel comprehensive biomarker (named PSI). Kaplan-Meier survival curves and log-rank tests were used to evaluate the prognostic impact of preoperative OPNI, SIRI, and PSI. Univariate and multivariate Cox regression model were conducted to identify independent prognostic factors for CRC. The receiver operating characteristic (ROC) method assessed the predictive ability of PSI, stage, OPNI, and SIRI.ResultsPatients with higher preoperative OPNI and lower SIRI values had significantly better overall survival (OS). PSI was identified as an independent prognostic factor for OS in both univariate and multivariate analysis. Patients with medium (28.3-43.4) and high (>43.4) PSI scores exhibited superior OS compared to those with low (≤ 28.3) PSI scores. PSI showed higher predictive ability (AUC: 0.734) than individual indicators alone (OPNI: 0.721, SIRI: 0.645, stage: 0.635).ConclusionThe novel indicator, PSI, based on preoperative SIRI and OPNI, demonstrated significant prognostic value for resectable CRC patients. PSI outperformed individual indicators and could serve as a reliable tool for prognostic evaluation in CRC patients. |
| first_indexed | 2024-03-10T05:50:12Z |
| format | Article |
| id | doaj.art-934bee262af243c9b4bc58f5f0d39eec |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-10T05:50:12Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-934bee262af243c9b4bc58f5f0d39eec2023-11-22T21:49:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-11-011310.3389/fonc.2023.12794871279487Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancerHao CaiJiancheng LiYu ChenQiao ZhangYang LiuHoujun JiaBackgroundColorectal cancer (CRC) remains a major global health concern, with significant morbidity and mortality rates. In this study, we aimed to develop a comprehensive blood indicator based on systemic inflammation and nutritional condition to predict the prognosis of resectable CRC patients.MethodsA retrospective cohort of 210 CRC patients who underwent radical resection at the First Affiliated Hospital of Chongqing Medical University, China, between January 2015 and December 2017, was included in the analysis. Baseline characteristics, preoperative blood markers, including neutrophil count, monocyte count, lymphocyte count, platelets, albumin, and CEA were retrospectively reviewed. Various blood indicators, such as NLR, PLR, MLR, SIRI and OPNI were calculated. The least absolute shrinkage and selection operator (LASSO) method was employed to select indicators to establish a novel comprehensive biomarker (named PSI). Kaplan-Meier survival curves and log-rank tests were used to evaluate the prognostic impact of preoperative OPNI, SIRI, and PSI. Univariate and multivariate Cox regression model were conducted to identify independent prognostic factors for CRC. The receiver operating characteristic (ROC) method assessed the predictive ability of PSI, stage, OPNI, and SIRI.ResultsPatients with higher preoperative OPNI and lower SIRI values had significantly better overall survival (OS). PSI was identified as an independent prognostic factor for OS in both univariate and multivariate analysis. Patients with medium (28.3-43.4) and high (>43.4) PSI scores exhibited superior OS compared to those with low (≤ 28.3) PSI scores. PSI showed higher predictive ability (AUC: 0.734) than individual indicators alone (OPNI: 0.721, SIRI: 0.645, stage: 0.635).ConclusionThe novel indicator, PSI, based on preoperative SIRI and OPNI, demonstrated significant prognostic value for resectable CRC patients. PSI outperformed individual indicators and could serve as a reliable tool for prognostic evaluation in CRC patients.https://www.frontiersin.org/articles/10.3389/fonc.2023.1279487/fullcolorectal cancerOnodera’ s prognostic nutritional indexprognosissystemic inflammation response indexhematological markers |
| spellingShingle | Hao Cai Jiancheng Li Yu Chen Qiao Zhang Yang Liu Houjun Jia Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer Frontiers in Oncology colorectal cancer Onodera’ s prognostic nutritional index prognosis systemic inflammation response index hematological markers |
| title | Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| title_full | Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| title_fullStr | Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| title_full_unstemmed | Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| title_short | Preoperative inflammation and nutrition-based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| title_sort | preoperative inflammation and nutrition based comprehensive biomarker for predicting prognosis in resectable colorectal cancer |
| topic | colorectal cancer Onodera’ s prognostic nutritional index prognosis systemic inflammation response index hematological markers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1279487/full |
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