p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer

p20BAP31 induces cell apoptosis via both AIF caspase-independent and the ROS/JNK mitochondrial pathway in colorectal cancer

Abstract Background During cell apoptosis, the C-terminus of BAP31 is cleaved by caspase-8 and generates p20BAP31, which has been shown to induce an apoptotic pathway between the endoplasmic reticulum (ER) and mitochondria. However, the underlying mechanisms of p20BAP31 in cell apoptosis remains unc...

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Bibliographic Details
Main Authors: Xiaohan Jiang, Guoxun Li, Benzhi Zhu, Jingnan Zang, Tian Lan, Rui Jiang, Bing Wang
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
p20BAP31
Apoptosis
AIF
ROS/JNK pathway
Colorectal cancer
Online Access:https://doi.org/10.1186/s11658-023-00434-z

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