Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome
Abstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigate...
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-01553-3 |
| _version_ | 1818934006063824896 |
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| author | Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu |
| author_facet | Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu |
| author_sort | Sule Cilekar |
| collection | DOAJ |
| description | Abstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea–hypopnea index, AHI 5–30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS. |
| first_indexed | 2024-12-20T04:57:24Z |
| format | Article |
| id | doaj.art-934ff3441a494333b0bcd55fa2029fb1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T04:57:24Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-934ff3441a494333b0bcd55fa2029fb12022-12-21T19:52:41ZengNature PortfolioScientific Reports2045-23222021-11-011111610.1038/s41598-021-01553-3Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndromeSule Cilekar0Selvihan Beysel1Savas Karatas2Aydin Balci3Kursad Akaslan4Ali Uncu5Department of Chest Diseases, Faculty of Medicine, Afyonkarahisar Health Sciences University, Chest Diseases ClinicDepartment of Endocrinology and Metabolism, Afyonkarahisar Health Science UniversityDepartment of Endocrinology and Metabolism, Istanbul Research and Education HospitalDepartment of Chest Diseases, Faculty of Medicine, Afyonkarahisar Health Sciences University, Chest Diseases ClinicIsıklar Family Health CenterEskisehir City Hospital Biochemistry DepartmentAbstract Hypoxia is linked to an inflammatory imbalance in obstructive sleep apnea syndrome (OSAS). Circulating soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) is a cytokine that regulates inflammation and insulin resistance in adipose tissue. This study first investigated sTWEAK concentrations in patients OSAS and evaluated associations between sTWEAK concentrations and visceral adiposity, metabolic dysfunction, and hypoxia observed in OSAS. Forty age, sex, and body mass index-matched patients with simple habitual snoring (HSS) and 70 patients with OSAS were included. Patients were divided according to OSAS severity: mild-moderate (apnea–hypopnea index, AHI 5–30 events/h) and severe (AHI ≥ 30 events/h). Anthropometric data, glucose metabolism, visceral fat (VF) ratio, and sTWEAK levels were compared. sTWEAK levels were higher in the OSAS group than in the HSS group (931.23 ± 136.48 vs. 735.22 ± 102.84 ng/L, p = 0.001). sTWEAK levels were higher in severe OSAS than in mild-moderate OSAS (1031.83 ± 146.69 vs. 891.01 ± 110.01 ng/L, p = 0.002. When we evaluated the sTWEAK value and AHI, VF ratio, total cholesterol, blood pressure, homeostasis model of assessment-insulin resistance, and high-sensitivity C-reactive protein using multiple regression analysis, a significant correlation was found between sTWEAK levels and AHI (p < 0.001). It was found that sTWEAK levels were not correlated with glucose metabolism and VF ratio. Increased circulating sTWEAK levels were associated with the severity of OSAS. High sTWEAK levels were correlated with increased AHI. sTWEAK concentrations are linked to severe OSAS.https://doi.org/10.1038/s41598-021-01553-3 |
| spellingShingle | Sule Cilekar Selvihan Beysel Savas Karatas Aydin Balci Kursad Akaslan Ali Uncu Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome Scientific Reports |
| title | Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| title_full | Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| title_fullStr | Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| title_full_unstemmed | Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| title_short | Circulating sTweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| title_sort | circulating stweak is associated with visceral adiposity and severity in patients with obstructive sleep apnea syndrome |
| url | https://doi.org/10.1038/s41598-021-01553-3 |
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