Targeting the INCENP IN-box–Aurora B interaction to inhibit CPC activity in vivo
The chromosome passenger complex (CPC) is an essential regulator of mitosis and cytokinesis. The CPC consists of Aurora B kinase, inner centromere protein (INCENP), and the targeting subunits survivin and borealin/Dasra B. INCENP is a scaffolding subunit for the CPC and activates Aurora B via its co...
Main Authors: | Florence H. Gohard, Daniel J. St-Cyr, Mike Tyers, William C. Earnshaw |
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Format: | Article |
Language: | English |
Published: |
The Royal Society
2014-01-01
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Series: | Open Biology |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140163 |
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