Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components
Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite pot...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SciELO
2024-01-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100201&lng=en&tlng=en |
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| author | Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes |
| author_facet | Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes |
| author_sort | Isadora Sousa de Oliveira |
| collection | DOAJ |
| description | Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil. |
| first_indexed | 2024-03-08T12:06:50Z |
| format | Article |
| id | doaj.art-9351dc123552445eb297ce246d3aae49 |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-03-08T12:06:50Z |
| publishDate | 2024-01-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-9351dc123552445eb297ce246d3aae492024-01-23T07:38:54ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992024-01-013010.1590/1678-9199-jvatitd-2023-0046Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight componentsIsadora Sousa de Oliveirahttps://orcid.org/0000-0002-2036-1191Nicoly Malachize Alano-da-SilvaIsabela Gobbo FerreiraFelipe Augusto CerniJacqueline de Almeida Gonçalves Sachetthttps://orcid.org/0000-0001-5723-9977Wuelton Marcelo Monteirohttps://orcid.org/0000-0002-0848-1940Manuela Berto Puccahttps://orcid.org/0000-0003-2594-7068Eliane Candiani Aranteshttps://orcid.org/0000-0002-6712-6033Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100201&lng=en&tlng=enTityus serrulatusProteasesHyaluronidasePhospholipaseCysteine-rich secretory proteins |
| spellingShingle | Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components Journal of Venomous Animals and Toxins including Tropical Diseases Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins |
| title | Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
| title_full | Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
| title_fullStr | Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
| title_full_unstemmed | Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
| title_short | Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
| title_sort | understanding the complexity of tityus serrulatus venom a focus on high molecular weight components |
| topic | Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100201&lng=en&tlng=en |
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