Association between oxidative stress and melanoma progression
Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformat...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Medical Biochemists of Serbia, Belgrade
2018-01-01
|
| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581801012P.pdf |
| _version_ | 1828472437952479232 |
|---|---|
| author | Pantić-Biševac Jelena Đukić Mirjana Stanojević Ivan Stevanović Ivana Mijušković Željko Đurić Ana Gobeljić Borko Banović Tatjana Vojvodić Danilo |
| author_facet | Pantić-Biševac Jelena Đukić Mirjana Stanojević Ivan Stevanović Ivana Mijušković Željko Đurić Ana Gobeljić Borko Banović Tatjana Vojvodić Danilo |
| author_sort | Pantić-Biševac Jelena |
| collection | DOAJ |
| description | Background: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondialdehyde highest value was in stage IV the activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level. |
| first_indexed | 2024-12-11T05:29:42Z |
| format | Article |
| id | doaj.art-9352a3d8acc648d4855d28cc044245f0 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-11T05:29:42Z |
| publishDate | 2018-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-9352a3d8acc648d4855d28cc044245f02022-12-22T01:19:28ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662018-01-0137112201452-82581801012PAssociation between oxidative stress and melanoma progressionPantić-Biševac Jelena0Đukić Mirjana1https://orcid.org/0000-0003-0177-1205Stanojević Ivan2Stevanović Ivana3Mijušković Željko4https://orcid.org/0000-0003-0924-1719Đurić Ana5https://orcid.org/0000-0002-4440-9890Gobeljić Borko6https://orcid.org/0000-0002-4371-0542Banović Tatjana7Vojvodić Danilo8https://orcid.org/0000-0001-9308-3076Military Medical Academy, Institute of Medical Biochemistry, BelgradeUniversity of Belgrade, Faculty of Pharmacy, Department of Toxicology, BelgradeMilitary Medical Academy, Institute for Medical Research, Belgrade + Ministry of Defense, University of Defense, Medical Faculty, BelgradeInstitute for Medical Research, Military Medical Academy, BelgradeMinistry of Defense, University of Defense, Medical Faculty, Belgrade + Military Medical Academy, Clinic of Dermatology, BelgradeUniversity of Belgrade, Faculty of Pharmacy, Department of Toxicology, BelgradeUniversity of Belgrade, Faculty of Pharmacy, Department of Toxicology, BelgradeRoyal Adelaide Hospital, SA Pathology, Department of Immunology, Adelaide, AustraliaMilitary Medical Academy, Institute for Medical Research, Belgrade + Ministry of Defense, University of Defense, Medical Faculty, BelgradeBackground: Overproduction of free radicals accompanied with their insufficient removal/neutralization by antioxidative defense system impairs redox hemostasis in living organisms. Oxidative stress has been shown to be involved in all the stages of carcinogenesis and malignant melanocyte transformation. The aim of this study was to examine association between oxidative stress development and different stages of melanoma. Methods: The measured oxidative stress parameters included: superoxide anion radical, total and manganese superoxide dismutase, catalase and malondialdehyde. Oxidative stress parameters were measured spectrophotometrically in serum samples from melanoma patients (n=72) and healthy control subjects (n=30). Patients were classified according to AJCC clinical stage. Results: Average superoxide anion and malondialdehyde concentrations were significantly higher in melanoma patients than in control group, with the highest value of superoxide anion in stage III, while malondialdehyde highest value was in stage IV the activity of total and manganese superoxide dismutase was insignificantly higher in melanoma patients than in control group, while catalase activity was significantly higher. The highest activity of total superoxide dismutase was in stage III, while the highest activity of manganese superoxide dismutase was in stage IV Catalase activity was increasing with the disease progression achieving the maximum in stage III. Conclusions: Results of our study suggest that melanoma is oxidative stress associated disease, as well as deteriorated cell functioning at mitochondrial level.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581801012P.pdfantioxidantsfree radicalsmelanomaoxidative stress |
| spellingShingle | Pantić-Biševac Jelena Đukić Mirjana Stanojević Ivan Stevanović Ivana Mijušković Željko Đurić Ana Gobeljić Borko Banović Tatjana Vojvodić Danilo Association between oxidative stress and melanoma progression Journal of Medical Biochemistry antioxidants free radicals melanoma oxidative stress |
| title | Association between oxidative stress and melanoma progression |
| title_full | Association between oxidative stress and melanoma progression |
| title_fullStr | Association between oxidative stress and melanoma progression |
| title_full_unstemmed | Association between oxidative stress and melanoma progression |
| title_short | Association between oxidative stress and melanoma progression |
| title_sort | association between oxidative stress and melanoma progression |
| topic | antioxidants free radicals melanoma oxidative stress |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2018/1452-82581801012P.pdf |
| work_keys_str_mv | AT panticbisevacjelena associationbetweenoxidativestressandmelanomaprogression AT đukicmirjana associationbetweenoxidativestressandmelanomaprogression AT stanojevicivan associationbetweenoxidativestressandmelanomaprogression AT stevanovicivana associationbetweenoxidativestressandmelanomaprogression AT mijuskoviczeljko associationbetweenoxidativestressandmelanomaprogression AT đuricana associationbetweenoxidativestressandmelanomaprogression AT gobeljicborko associationbetweenoxidativestressandmelanomaprogression AT banovictatjana associationbetweenoxidativestressandmelanomaprogression AT vojvodicdanilo associationbetweenoxidativestressandmelanomaprogression |