Wnt signaling in synaptogenesis of Alzheimer's disease
Abstract Alzheimer's disease (AD), recognized as the leading cause of dementia, occupies a prominent position on the list of significant neurodegenerative disorders, representing a significant global health concern with far‐reaching implications at both individual and societal levels. The prima...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-09-01
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| Series: | Ibrain |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ibra.12130 |
| _version_ | 1827816699974385664 |
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| author | Cheng‐Ting Zhang Joy Wang Wen‐Yuan Wang |
| author_facet | Cheng‐Ting Zhang Joy Wang Wen‐Yuan Wang |
| author_sort | Cheng‐Ting Zhang |
| collection | DOAJ |
| description | Abstract Alzheimer's disease (AD), recognized as the leading cause of dementia, occupies a prominent position on the list of significant neurodegenerative disorders, representing a significant global health concern with far‐reaching implications at both individual and societal levels. The primary symptom of Alzheimer's disease is a decrease in synaptic potency along with synaptic connection loss. Synapses, which act as important linkages between neuronal units within the cerebral region, are critical in signal transduction processes essential to orchestrating cognitive tasks. Synaptic connections act as critical interconnections between neuronal cells inside the cerebral environment, facilitating critical signal transduction processes required for cognitive functions. The confluence of axonal and dendritic filopodial extensions culminates in the creation of intercellular connections, coordinated by various signals and molecular mechanisms. The progression of synaptic maturation and plasticity is a critical determinant in maintaining mental well‐being, and abnormalities in these processes have been linked to the development of neurodegenerative diseases. Wnt signaling pathways are important to the orchestration of synapse development. This review examines the complicated interplay between Wnt signaling and dendritic filopodia, including an examination of the regulatory complexities and molecular machinations involved in synaptogenesis progression. Then, these findings are contextualized within the context of AD pathology, allowing for the consideration of prospective therapeutic approaches based on the findings and development of novel avenues for future scientific research. |
| first_indexed | 2024-03-12T00:23:13Z |
| format | Article |
| id | doaj.art-935408677ec8442ea1ce811f17359cf9 |
| institution | Directory Open Access Journal |
| issn | 2769-2795 |
| language | English |
| last_indexed | 2024-03-12T00:23:13Z |
| publishDate | 2023-09-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj.art-935408677ec8442ea1ce811f17359cf92023-09-15T11:51:24ZengWiley-VCHIbrain2769-27952023-09-019331632510.1002/ibra.12130Wnt signaling in synaptogenesis of Alzheimer's diseaseCheng‐Ting Zhang0Joy Wang1Wen‐Yuan Wang2Living Systems Institute University of Exeter Exeter UKWinchester High School Winchester Massachusetts USAInterdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Science Shanghai ChinaAbstract Alzheimer's disease (AD), recognized as the leading cause of dementia, occupies a prominent position on the list of significant neurodegenerative disorders, representing a significant global health concern with far‐reaching implications at both individual and societal levels. The primary symptom of Alzheimer's disease is a decrease in synaptic potency along with synaptic connection loss. Synapses, which act as important linkages between neuronal units within the cerebral region, are critical in signal transduction processes essential to orchestrating cognitive tasks. Synaptic connections act as critical interconnections between neuronal cells inside the cerebral environment, facilitating critical signal transduction processes required for cognitive functions. The confluence of axonal and dendritic filopodial extensions culminates in the creation of intercellular connections, coordinated by various signals and molecular mechanisms. The progression of synaptic maturation and plasticity is a critical determinant in maintaining mental well‐being, and abnormalities in these processes have been linked to the development of neurodegenerative diseases. Wnt signaling pathways are important to the orchestration of synapse development. This review examines the complicated interplay between Wnt signaling and dendritic filopodia, including an examination of the regulatory complexities and molecular machinations involved in synaptogenesis progression. Then, these findings are contextualized within the context of AD pathology, allowing for the consideration of prospective therapeutic approaches based on the findings and development of novel avenues for future scientific research.https://doi.org/10.1002/ibra.12130ADdendritic filopodiasynaptogenesisWnt |
| spellingShingle | Cheng‐Ting Zhang Joy Wang Wen‐Yuan Wang Wnt signaling in synaptogenesis of Alzheimer's disease Ibrain AD dendritic filopodia synaptogenesis Wnt |
| title | Wnt signaling in synaptogenesis of Alzheimer's disease |
| title_full | Wnt signaling in synaptogenesis of Alzheimer's disease |
| title_fullStr | Wnt signaling in synaptogenesis of Alzheimer's disease |
| title_full_unstemmed | Wnt signaling in synaptogenesis of Alzheimer's disease |
| title_short | Wnt signaling in synaptogenesis of Alzheimer's disease |
| title_sort | wnt signaling in synaptogenesis of alzheimer s disease |
| topic | AD dendritic filopodia synaptogenesis Wnt |
| url | https://doi.org/10.1002/ibra.12130 |
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