Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

The SR protein splicing factor SRSF1 is a potent proto-oncogene that is frequently upregulated in cancer. Here, we show that SRSF1 is a direct target of the transcription factor oncoprotein MYC. These two oncogenes are significantly coexpressed in lung carcinomas, and MYC knockdown downregulates SRS...

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Bibliographic Details
Main Authors: Shipra Das, Olga Anczuków, Martin Akerman, Adrian R. Krainer
Format: Article
Language:English
Published: Elsevier 2012-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124711000118

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