Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease

Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease

Abstract In pursuit of treating Parkinson’s disease with cell replacement therapy, differentiated induced pluripotent stem cells (iPSC) are an ideal source of midbrain dopaminergic (mDA) cells. We previously established a protocol for differentiating iPSC-derived post-mitotic mDA neurons capable of...

Full description

Bibliographic Details
Main Authors:	Benjamin M. Hiller, David J. Marmion, Cayla A. Thompson, Nathaniel A. Elliott, Howard Federoff, Patrik Brundin, Virginia B. Mattis, Christopher W. McMahon, Jeffrey H. Kordower
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-04-01
Series:	npj Regenerative Medicine
Online Access:	https://doi.org/10.1038/s41536-022-00221-y

Similar Items

Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo
by: Dustin R. Wakeman, et al.
Published: (2017-07-01)

Mitomycin‐C treatment during differentiation of induced pluripotent stem cell‐derived dopamine neurons reduces proliferation without compromising survival or function in vivo
by: Benjamin M. Hiller, et al.
Published: (2021-02-01)

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
by: Maria G. Otero, et al.
Published: (2023-09-01)

Maturing iPSC-Derived Cardiomyocytes
by: Bor Luen Tang
Published: (2020-01-01)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
by: Beccano-Kelly, DA, et al.
Published: (2023)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
by: Dayne A. Beccano-Kelly, et al.
Published: (2023-07-01)

Human Huntington’s Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation
by: Shagun R. Mehta, et al.
Published: (2018-10-01)

Pro-maturational effects of human iPSC-derived cortical astrocytes upon iPSC-derived cortical neurons
by: Anne Hedegaard, et al.
Published: (2020)

Automated high-content imaging in iPSC-derived neuronal progenitors
by: Apostolos Papandreou, et al.
Published: (2023-03-01)

Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
by: Suzy Varderidou-Minasian, et al.
Published: (2020-05-01)

MAPT genetic variation and neuronal maturity alter isoform expression affecting axonal transport in iPSC-derived dopamine neurons.
by: Beevers, J, et al.
Published: (2017)

MAPT Genetic Variation and Neuronal Maturity Alter Isoform Expression Affecting Axonal Transport in iPSC-Derived Dopamine Neurons
by: Joel E. Beevers, et al.
Published: (2017-08-01)

The Global Alliance for iPSC Therapies (GAiT)
by: Stephen Sullivan, et al.
Published: (2020-12-01)

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
by: G. Cappelletti, et al.
Published: (2023-12-01)

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
by: Kaixuan Zhao, et al.
Published: (2022-01-01)

Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation
by: Miho Isoda, et al.
Published: (2023-06-01)

The CIRM iPSC repository
by: Stephen S. Lin, et al.
Published: (2020-04-01)

CiRA iPSC seed stocks (CiRA's iPSC Stock Project)
by: Tadaaki Hanatani, et al.
Published: (2021-01-01)

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons
by: Zambon, F, et al.
Published: (2019)

The adult environment promotes the transcriptional maturation of human iPSC-derived muscle grafts
by: Sarah B. Crist, et al.
Published: (2024-04-01)

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons
by: Javier Emperador Melero, et al.
Published: (2017-03-01)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
by: Christian Zuppinger, et al.
Published: (2017-06-01)

Bankable human iPSC-derived retinal progenitors represent a valuable source of multipotent cells
by: Sandy Gozlan, et al.
Published: (2023-07-01)

FMR1 Reactivating Treatments in Fragile X iPSC-Derived Neural Progenitors In Vitro and In Vivo
by: Dan Vershkov, et al.
Published: (2019-03-01)

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice
by: Corinne Haller, et al.
Published: (2019-04-01)

Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1
by: Bumpei Samata, et al.
Published: (2016-10-01)

Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors.
by: Andrew A Sproul, et al.
Published: (2014-01-01)

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids
by: Ran-Ran Zhang, et al.
Published: (2018-03-01)

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism
by: Ng, J, et al.
Published: (2021)

Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells
by: Christiane Loerch, et al.
Published: (2024-04-01)

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures
by: Siiri Suominen, et al.
Published: (2023-09-01)

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
by: Sofija Vučković, et al.
Published: (2022-07-01)

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation
by: Heidrun Vethe, et al.
Published: (2019-05-01)

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
by: Kenji Miki, et al.
Published: (2021-06-01)

iPSC for modeling neurodegenerative disorders
by: Valeria Valadez-Barba, et al.
Published: (2020-12-01)

Metabolic Changes during In Vivo Maturation of PSC-Derived Skeletal Myogenic Progenitors
by: Phablo Abreu, et al.
Published: (2023-12-01)

Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice
by: Takayuki Kondo, et al.
Published: (2014-08-01)

Altered Differentiation Potential of Gaucherâs Disease iPSC Neuronal Progenitors due to Wnt/Î²-Catenin Downregulation
by: Ola Awad, et al.
Published: (2017-12-01)

Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
by: Andrea M. Reyes-Ortiz, et al.
Published: (2023-01-01)

Generation of iPSC line iPSC-FH2.1 in hypoxic conditions from human foreskin fibroblasts
by: María Questa, et al.
Published: (2016-03-01)