Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples

Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples

Abstract Introduction The thrombin generation (TG) test is a global hemostasis assay sensitive to procoagulant conditions. However, some TG assays may underestimate elevated TG when the thrombin fluorogenic substrate is depleted or fluorescence is attenuated by the inner filter effect (IFE). Objecti...

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Bibliographic Details
Main Authors:	William C. Chang, Joseph W. Jackson, Kellie R. Machlus, Alisa S. Wolberg, Mikhail V. Ovanesov
Format:	Article
Language:	English
Published:	Elsevier 2021-03-01
Series:	Research and Practice in Thrombosis and Haemostasis
Subjects:	blood coagulation factors calibration hemostasis plasma thrombin
Online Access:	https://doi.org/10.1002/rth2.12499

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