Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates
Reward modulation is represented in the motor cortex (M1) and could be used to implement more accurate decoding models to improve brain-computer interfaces (BCIs; Zhao et al., 2018). Analyzing trial-to-trial noise-correlations between neural units in the presence of rewarding (R) and non-rewarding (...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2020.541920/full |
| _version_ | 1818919607719690240 |
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| author | Brittany Moore Sheng Khang Joseph Thachil Francis Joseph Thachil Francis |
| author_facet | Brittany Moore Sheng Khang Joseph Thachil Francis Joseph Thachil Francis |
| author_sort | Brittany Moore |
| collection | DOAJ |
| description | Reward modulation is represented in the motor cortex (M1) and could be used to implement more accurate decoding models to improve brain-computer interfaces (BCIs; Zhao et al., 2018). Analyzing trial-to-trial noise-correlations between neural units in the presence of rewarding (R) and non-rewarding (NR) stimuli adds to our understanding of cortical network dynamics. We utilized Pearson’s correlation coefficient to measure shared variability between simultaneously recorded units (32–112) and found significantly higher noise-correlation and positive correlation between the populations’ signal- and noise-correlation during NR trials as compared to R trials. This pattern is evident in data from two non-human primates (NHPs) during single-target center out reaching tasks, both manual and action observation versions. We conducted a mean matched noise-correlation analysis to decouple known interactions between event-triggered firing rate changes and neural correlations. Isolated reward discriminatory units demonstrated stronger correlational changes than units unresponsive to reward firing rate modulation, however, the qualitative response was similar, indicating correlational changes within the network as a whole can serve as another information channel to be exploited by BCIs that track the underlying cortical state, such as reward expectation, or attentional modulation. Reward expectation and attention in return can be utilized with reinforcement learning (RL) towards autonomous BCI updating. |
| first_indexed | 2024-12-20T01:08:33Z |
| format | Article |
| id | doaj.art-93606bf844524bb9899f7b7af960ac08 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T01:08:33Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-93606bf844524bb9899f7b7af960ac082022-12-21T19:58:46ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532020-12-011410.3389/fnbeh.2020.541920541920Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in PrimatesBrittany Moore0Sheng Khang1Joseph Thachil Francis2Joseph Thachil Francis3Department of Biomedical Engineering, Cullen College of Engineering, The University of Houston, Houston, TX, United StatesDepartment of Biomedical Engineering, Cullen College of Engineering, The University of Houston, Houston, TX, United StatesDepartment of Biomedical Engineering, Cullen College of Engineering, The University of Houston, Houston, TX, United StatesDepartment of Electrical and Computer Engineering, Cullen College of Engineering, The University of Houston, Houston, TX, United StatesReward modulation is represented in the motor cortex (M1) and could be used to implement more accurate decoding models to improve brain-computer interfaces (BCIs; Zhao et al., 2018). Analyzing trial-to-trial noise-correlations between neural units in the presence of rewarding (R) and non-rewarding (NR) stimuli adds to our understanding of cortical network dynamics. We utilized Pearson’s correlation coefficient to measure shared variability between simultaneously recorded units (32–112) and found significantly higher noise-correlation and positive correlation between the populations’ signal- and noise-correlation during NR trials as compared to R trials. This pattern is evident in data from two non-human primates (NHPs) during single-target center out reaching tasks, both manual and action observation versions. We conducted a mean matched noise-correlation analysis to decouple known interactions between event-triggered firing rate changes and neural correlations. Isolated reward discriminatory units demonstrated stronger correlational changes than units unresponsive to reward firing rate modulation, however, the qualitative response was similar, indicating correlational changes within the network as a whole can serve as another information channel to be exploited by BCIs that track the underlying cortical state, such as reward expectation, or attentional modulation. Reward expectation and attention in return can be utilized with reinforcement learning (RL) towards autonomous BCI updating.https://www.frontiersin.org/articles/10.3389/fnbeh.2020.541920/fullmotor cortexrewardreinforcement learningtemporal differencereward predictionreward prediction error |
| spellingShingle | Brittany Moore Sheng Khang Joseph Thachil Francis Joseph Thachil Francis Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates Frontiers in Behavioral Neuroscience motor cortex reward reinforcement learning temporal difference reward prediction reward prediction error |
| title | Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates |
| title_full | Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates |
| title_fullStr | Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates |
| title_full_unstemmed | Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates |
| title_short | Noise-Correlation Is Modulated by Reward Expectation in the Primary Motor Cortex Bilaterally During Manual and Observational Tasks in Primates |
| title_sort | noise correlation is modulated by reward expectation in the primary motor cortex bilaterally during manual and observational tasks in primates |
| topic | motor cortex reward reinforcement learning temporal difference reward prediction reward prediction error |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2020.541920/full |
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