Venous Thromboembolism in Japanese Patients with Gynecologic Cancer
Objective Gynecologic cancer, including cervical, endometrial, and ovarian cancer, comprises the fifth leading type of cancer and is an important malignant disease in women. Previous studies in Western countries have reported respective prevalence rates for venous thromboembolism (VTE) of 3.3%–18.7%...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221124121 |
| _version_ | 1811174245047205888 |
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| author | Takahito Suzuki MD Shota Tsurimoto MD Takayasu Tada MD Ryo Yamamura MD Hiromasa Katoh MD Yoshihiro Noji MD Masato Yamaguchi MD Susumu Fujino MD |
| author_facet | Takahito Suzuki MD Shota Tsurimoto MD Takayasu Tada MD Ryo Yamamura MD Hiromasa Katoh MD Yoshihiro Noji MD Masato Yamaguchi MD Susumu Fujino MD |
| author_sort | Takahito Suzuki MD |
| collection | DOAJ |
| description | Objective Gynecologic cancer, including cervical, endometrial, and ovarian cancer, comprises the fifth leading type of cancer and is an important malignant disease in women. Previous studies in Western countries have reported respective prevalence rates for venous thromboembolism (VTE) of 3.3%–18.7%, 0.8%–8.1%, and 7.2%–20.9%. In this study, we aimed to identify the characteristics associated with VTE in Japanese patients. Methods We carried out a retrospective cohort study to compare the clinicopathological characteristics of patients with each gynecologic cancer with and without concomitant VTE. Patients: Patients with cervical, endometrial, or ovarian cancer treated at Fukui Prefectural Hospital, Japan, from April 2010 to March 2020. Results Among 699 patients with gynecologic cancer, 50 developed VTE within 5 years after their cancer diagnosis, including 16/357 patients with cervical cancer (5.6%), 12/185 with endometrial cancer (6.8%), and 22/157 with ovarian cancer (14.6%). The 1-year mortality rate after symptomatic VTE onset was 47.8%. The VTE group included significantly more older patients and more patients with advanced cancer or poor performance status compared with the non-VTE group. There was no significant difference in the rate of surgical treatment. Symptomatic, but not asymptomatic VTE, was associated with shorter survival. Conclusion Several baseline characteristics differed between patients with and without VTE. The incidences of VTE and some risk factors were similar in Japanese patients with gynecologic cancers compared with patients in other countries. Patients with VTE had some factors that worsened their prognosis, with patients with gynecologic cancer and symptomatic VTE having an especially poor prognosis. |
| first_indexed | 2024-04-10T18:58:04Z |
| format | Article |
| id | doaj.art-936113fbb0364a23830daa05d88ef0e0 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-10T18:58:04Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-936113fbb0364a23830daa05d88ef0e02023-01-31T16:34:45ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232023-01-012910.1177/10760296221124121Venous Thromboembolism in Japanese Patients with Gynecologic CancerTakahito Suzuki MDShota Tsurimoto MDTakayasu Tada MDRyo Yamamura MDHiromasa Katoh MDYoshihiro Noji MDMasato Yamaguchi MDSusumu Fujino MDObjective Gynecologic cancer, including cervical, endometrial, and ovarian cancer, comprises the fifth leading type of cancer and is an important malignant disease in women. Previous studies in Western countries have reported respective prevalence rates for venous thromboembolism (VTE) of 3.3%–18.7%, 0.8%–8.1%, and 7.2%–20.9%. In this study, we aimed to identify the characteristics associated with VTE in Japanese patients. Methods We carried out a retrospective cohort study to compare the clinicopathological characteristics of patients with each gynecologic cancer with and without concomitant VTE. Patients: Patients with cervical, endometrial, or ovarian cancer treated at Fukui Prefectural Hospital, Japan, from April 2010 to March 2020. Results Among 699 patients with gynecologic cancer, 50 developed VTE within 5 years after their cancer diagnosis, including 16/357 patients with cervical cancer (5.6%), 12/185 with endometrial cancer (6.8%), and 22/157 with ovarian cancer (14.6%). The 1-year mortality rate after symptomatic VTE onset was 47.8%. The VTE group included significantly more older patients and more patients with advanced cancer or poor performance status compared with the non-VTE group. There was no significant difference in the rate of surgical treatment. Symptomatic, but not asymptomatic VTE, was associated with shorter survival. Conclusion Several baseline characteristics differed between patients with and without VTE. The incidences of VTE and some risk factors were similar in Japanese patients with gynecologic cancers compared with patients in other countries. Patients with VTE had some factors that worsened their prognosis, with patients with gynecologic cancer and symptomatic VTE having an especially poor prognosis.https://doi.org/10.1177/10760296221124121 |
| spellingShingle | Takahito Suzuki MD Shota Tsurimoto MD Takayasu Tada MD Ryo Yamamura MD Hiromasa Katoh MD Yoshihiro Noji MD Masato Yamaguchi MD Susumu Fujino MD Venous Thromboembolism in Japanese Patients with Gynecologic Cancer Clinical and Applied Thrombosis/Hemostasis |
| title | Venous Thromboembolism in Japanese Patients with Gynecologic Cancer |
| title_full | Venous Thromboembolism in Japanese Patients with Gynecologic Cancer |
| title_fullStr | Venous Thromboembolism in Japanese Patients with Gynecologic Cancer |
| title_full_unstemmed | Venous Thromboembolism in Japanese Patients with Gynecologic Cancer |
| title_short | Venous Thromboembolism in Japanese Patients with Gynecologic Cancer |
| title_sort | venous thromboembolism in japanese patients with gynecologic cancer |
| url | https://doi.org/10.1177/10760296221124121 |
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